PMID: 1201763Nov 21, 1975Paper

Alteration of drug metabolism during cholestasis in man

European Journal of Clinical Investigation
N CarulliM Gallo

Abstract

The morphological and functional alterations of the smooth endoplasmic reticulum of the liver cell related to biliary stasis have brought attention to drug biotransformation during cholestasis. The metabolism of meprobamate, pentobarbital and tolbutamide was assessed in subjects with intrahepatic recurrent cholestasis (3), cholestatic hepatitis (6), extrahepatic biliary obstruction (7) and normal controls (16). In the patients with recurrent intrahepatic cholestasis no differences in drug metabolism were noted as compared to the control group. In cholestatic hepatitis the plasma half-lives of meprobamate (828 +/- 422 min.) and pentobarbital (39+-65) were significantly longer than in in controls (444 +/- 37 and 25.4 +/- 1.1 respectively). Tolbutamide plasma half-life appeared unchanged. The most striking variations were observed in the patients with extrahepatic biliary obstruction. In such cases while meprobamate half-life was unchanged, pentobarbital half-life was significantly prolonged (31.2 +/- 2.5) and the in vitro metabolism of the drug, using liver preparations, was decreased to less than 50% of the control value. In contrast the metabolism of tolbutamide was accelerated as evidenced by a significant decrease of plasma h...Continue Reading

References

Mar 1, 1972·European Journal of Clinical Pharmacology·B SchoeneH F von Oldershausen
Feb 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·F HuttererH Popper
Aug 8, 1970·Life Sciences. Pt. 2: Biochemistry, General and Molecular Biology·F HuttererH Popper
Sep 1, 1971·European Journal of Clinical Investigation·N CarulliG F Salvioli
Sep 1, 1971·British Journal of Pharmacology·C D Klaassen
Jan 15, 1969·Klinische Wochenschrift·H Held, H F von Oldershausen
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Jul 1, 1966·Journal of Medicinal Chemistry·R C Thomas, G J Ikeda

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Citations

Jan 1, 1996·British Journal of Pharmacology·J WójcickiL Rózewicka
Dec 24, 1997·The Journal of Pharmacy and Pharmacology·M WójcickiJ Zakrzewski
Oct 24, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·M WójcickiL Rózewicka

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