Alteration of drug responsiveness in guinea-pig lung anaphylaxis using different antigen challenge concentrations

Agents and Actions
A J LewisA Dervinis

Abstract

Antihistamine-resistant anaphylactic bronchospasm in guinea pigs is increased with increasing doses of antigen (ovalbumin, OA) challenge. This was observed in passively and actively sensitized animals, and by both i.v. and aerosol routes of antigen challenge. At a challenge concentration of 100 mg/kg OA, antihistamines were virtually inactive. Indeed, the resulting bronchospasm was inhibited by isoproterenol, theophylline and ketotifen but not any anticholinergics, anti-5HT, SRS-A antagonists, arachidonic acid lipoxygenase inhibitors or antiallergic drugs. However, in the presence of chlorpheniramine, the response was antagonized by SRS-A antagonists (FPL 55712 and isamoxole), but not the lipoxygenase inhibitors (BW 755C, ETYA, NDGA and phenidone). This suggests that the antihistamine-resistant bronchospasm produced in guinea pigs challenged with high antigen concentrations might be the result of SRS-A release. This is by no means certain since the currently available SRS-A antagonists possess other mechanisms of action; furthermore, the failure of lipoxygenase inhibitors to influence this response is not consistent with a role for SRS-A. Elucidation of the mechanism of the antihistamine-resistant bronchospasm awaits developmen...Continue Reading

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Related Concepts

Anticholinergic mydriatics and cycloplegics
Anaphylaxis (Non Medication)
Lung
Isamoxole
Anticholinergics inhalants for obstructive airway diseases
Cavia
Phenidone
Kloromin
Arachidonate 15-Lipoxygenase Inhibitors
Bronchial Spasm

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Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.