Abstract
Antihistamine-resistant anaphylactic bronchospasm in guinea pigs is increased with increasing doses of antigen (ovalbumin, OA) challenge. This was observed in passively and actively sensitized animals, and by both i.v. and aerosol routes of antigen challenge. At a challenge concentration of 100 mg/kg OA, antihistamines were virtually inactive. Indeed, the resulting bronchospasm was inhibited by isoproterenol, theophylline and ketotifen but not any anticholinergics, anti-5HT, SRS-A antagonists, arachidonic acid lipoxygenase inhibitors or antiallergic drugs. However, in the presence of chlorpheniramine, the response was antagonized by SRS-A antagonists (FPL 55712 and isamoxole), but not the lipoxygenase inhibitors (BW 755C, ETYA, NDGA and phenidone). This suggests that the antihistamine-resistant bronchospasm produced in guinea pigs challenged with high antigen concentrations might be the result of SRS-A release. This is by no means certain since the currently available SRS-A antagonists possess other mechanisms of action; furthermore, the failure of lipoxygenase inhibitors to influence this response is not consistent with a role for SRS-A. Elucidation of the mechanism of the antihistamine-resistant bronchospasm awaits developmen...Continue Reading
References
Jan 1, 1977·Pharmacology & Therapeutics. Part B: General & Systematic Pharmacology·P J Piper
Jan 1, 1978·Biochemical Pharmacology·M Chasin, C Scott
Jan 1, 1978·British Journal of Pharmacology·J M ArmstrongJ R Vane
Jan 1, 1978·Pharmacology·Z E Mielens
Jan 1, 1971·International Archives of Allergy and Applied Immunology·D T Okpako
Oct 17, 1973·Nature: New Biology·J AugsteinM L Tattersall
Apr 9, 1981·European Journal of Pharmacology·J F Burka, N A Paterson
Sep 10, 1981·Nature·R A Lewis, K F Austen
May 1, 1981·Prostaglandins·P J Piper, M N Samhoun
May 21, 1982·European Journal of Pharmacology·A J LewisM E Rosenthale
Jun 1, 1981·Biochemical Pharmacology·A F WeltonJ G Hamilton
Jan 1, 1980·British Journal of Pharmacology·W Dawson, W J Sweatman
Jul 10, 1981·European Journal of Pharmacology·B B VargaftigR C Murphy
Sep 1, 1981·Prostaglandins·R D KrellD Bryan
Sep 1, 1981·Prostaglandins·R D KrellL Vickery
Jul 25, 1980·European Journal of Pharmacology·B B VargaftigJ Benveniste
Sep 1, 1981·Biochemical Pharmacology·G FolcoE Graström
Citations
Jun 1, 1986·Agents and Actions·A J LewisW C Daniel
Dec 1, 1984·Agents and Actions·A J LewisJ Chang
Dec 1, 1991·Lipids·H O Heuer
Nov 13, 1984·European Journal of Pharmacology·P SchiantarelliG Folco
Jun 20, 1989·European Journal of Pharmacology·J S FranzoneP Biffignandi
Jun 25, 1991·European Journal of Pharmacology·H O Heuer
Nov 14, 1994·European Journal of Pharmacology·R E HowellK D Laemont
Mar 1, 1987·Journal of Pharmacological Methods·A N Payne, G de Nucci
May 1, 1997·European Journal of Pharmacology·K M StuhlmeierF H Bach
Jan 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Arul VeerappanRandi B Silver
Dec 1, 1987·Pharmacological Research Communications·J P TarayreJ P Couzinier
Jul 1, 1987·British Journal of Pharmacology·L DaffonchioB J Whittle
Apr 1, 1988·The Journal of Pharmacy and Pharmacology·A Subissi, M Del Monte
Apr 1, 1985·British Journal of Pharmacology·A DetsouliB B Vargaftig
Jul 1, 1984·Acta Pharmacologica Et Toxicologica·M DahlbäckL Sörenby