PMID: 9442921Jan 27, 1998Paper

Alteration of endogenous antioxidant enzymes in naturally occurring hypertrophic cardiomyopathy

Biochemistry and Molecular Biology International
C S LinS J Mao

Abstract

We have recently developed a porcine model with naturally occurring hypertrophic cardiomyopathy (HCM). Similar to humans, occluded intramural coronary artery and damaged mitochondria are frequently observed in these animals in which the disease is thought to be associated with the local ischemia of myocardium. In view of antioxidant functions involved in the ischemic injury, we measured the expression of endogenous antioxidant enzymes in the tissues with and without HCM. The results showed a significant increase of Cu,Zn-superoxide dismutase (SOD), but not Mn-SOD, and decrease of catalase (CAT) activities in the various areas of HCM hearts. It was demonstrated that SOD/CAT ratios in the HCM hearts were significantly higher than those in normals and were found to be dramatically correlated with the severity of cardiac hypertrophy. The altered SOD/CAT ratio was also consistent with increase in lipid damage. We hypothesize that the elevated SOD combined with an inadequate amount of H2O2 scavenging enzyme may lead HCM heart at oxidative stress risk. However, the pathogenic role of imbalanced antioxidant enzyme needs to be further explored.

Citations

Apr 24, 2001·Pharmacology & Therapeutics·S K Wattanapitayakul, J A Bauer
Feb 1, 2000·Journal of Molecular and Cellular Cardiology·A T BäumerM Böhm
Mar 15, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Liselotte B ChristiansenTakashi Yokota
Dec 18, 2019·Journal of Clinical Medicine·Claudia SacchettoMartina Calore

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.

Related Papers

Biochemistry and Molecular Biology International
J Marin-GarciaD Mirvis
Medical Hypotheses
D Romero-AlviraL Placer
European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
A BochenekH Gryzbek
© 2021 Meta ULC. All rights reserved