Alteration of endothelin-1 concentration in STZ-induced diabetic rat nephropathy. Effects of a PGI(2) derivative

Hormone Research
Y ItohM Itoh

Abstract

Recently, an endothelin (ET-1) with a potent vasoconstrictive activity and stimulative activity of vascular muscular cell growth was discovered and blood ET-1 levels were higher in diabetic patients than in healthy subjects, suggesting that high ET-1 levels assist development and progression of diabetic microangiography. We examined renal function, and serum and tissue ET-1 levels in streptozotocin (STZ)-induced diabetic rats treated with a prostaglandin (PG) I(2) derivative to investigate the effect of PGI(2) in diabetic vascular disturbance. Renal weight, urinary albumin, urinary N-acetyl-beta,D-glucosaminidase (NAG) and serum ET-1 levels increased in STZ-induced diabetic rats, and a tendency to increase in renal tissue ET-1 levels was observed. Furthermore, electron-microscopic findings in the kidneys showed mesangial cell proliferation and mesangial matrix expansion which might be caused by diabetic nephropathy. The PGI(2) derivative reduced urinary albumin and NAG levels in STZ-induced rats. It was considered, therefore, that the PGI(2) derivative is effective in diabetic nephropathy. As the PGI(2) derivative also reduced renal tissue ET-1 levels, improvement of diabetic nephropathy partially was considered to result from ...Continue Reading

Citations

Aug 6, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Juan F NavarroJavier Garca
Apr 12, 2014·Journal of the American Society of Nephrology : JASN·Olivia LenoirPierre-Louis Tharaux
Jun 26, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alexander G MinchenkoIrina G Obrosova
Jul 12, 2005·American Journal of Physiology. Renal Physiology·Rania Nasrallah, Richard L Hébert

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