Alteration of enteric monoamines with monoamine receptors and colonic dysmotility in 6-hydroxydopamine-induced Parkinson's disease rats

Translational Research : the Journal of Laboratory and Clinical Medicine
Xiao-Li ZhangJin-Xia Zhu

Abstract

Constipation is common in Parkinson's disease (PD), in which monoamines (dopamine [DA], norepinephrine [NE], and 5-hydroxytryptamine [5-HT]) play an important role. Rats microinjected with 6-hydroxydopamine (6-OHDA) into the bilateral substantia nigra (SN) exhibit constipation, but the role of monoamines and their receptors is not clear. In the present study, colonic motility, monoamine content, and the expression of monoamine receptors were examined using strain gauge force transducers, ultraperformance liquid chromatography tandem mass spectrometry, immunofluorescence, and Western blot. The 6-OHDA rats displayed a significant reduction in dopaminergic neurons in the SN and a decreased time on rota-rod test and a marked decrease in daily fecal production and fecal water content. The amplitude of colonic spontaneous contraction was obviously decreased in 6-OHDA rats. Blocking D1-like receptor and β3-adrenoceptor (β3-AR) significantly reduced the inhibition of DA and NE on the colonic motility, respectively, whereas the 5-HT and 5-HT4 receptor agonists promoted the colonic motility. Moreover, DA content was increased in the colonic muscularis externa of 6-OHDA rats. The protein expression of β3-ARs was notably upregulated, but 5...Continue Reading

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Citations

Aug 31, 2016·Proceedings of the National Academy of Sciences of the United States of America·Weipang ChangJianguo G Gu
Jun 30, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C-Z LiuJ-X Zhu
Jan 10, 2019·American Journal of Physiology. Cell Physiology·Yun LiJin-Xia Zhu
Sep 2, 2020·Pflügers Archiv : European journal of physiology·Motoshi OkumuraKei Sonoyama
Oct 4, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G LevandisF Blandini
Sep 10, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C PellegriniM Fornai
Jul 7, 2020·Frontiers in Neuroscience·Jana HarsanyiovaAlzbeta Kralova Trancikova
Feb 11, 2020·Expert Opinion on Pharmacotherapy·Shilan MozaffariMohammad Abdollahi
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Jan 4, 2019·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Jeanette M Metzger, Marina E Emborg
May 4, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Hiroyuki NakamoriHikaru Hashitani
Jul 2, 2021·The Journal of Clinical Investigation·Alpana SinghSubhash Kulkarni

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