Alteration of erythrocyte glutathione, cysteine and glutathione synthetase in alcoholic and non-alcoholic cirrhosis

Scandinavian Journal of Clinical and Laboratory Investigation
C LoguercioG Nardi

Abstract

Glutathione (GSH) and cysteine were determined in the plasma and the erythrocytes of alcoholic and non-alcoholic cirrhotics as fluorescent monobromobimane derivatives by high-performance liquid chromatography (HPLC). Cirrhotic patients displayed a significant decrease of plasma GSH, as well as of plasma cysteine, that was related to the degree of liver disease but not to the nutritional conditions. On the contrary, erythrocyte cysteine was found to increase significantly in all cirrhotics, particularly in alcoholics, regardless of the severity of disease. In an attempt to find a possible explanation of these alterations, the GSH synthesizing enzymes, gamma-glutamylcysteine synthetase (GC-s) and GSH synthetase (GSH-s) activities were determined in the erythrocytes. GSH-s activity was significantly lower in cirrhotic patients, whereas GC-s activity did not differ in the three groups.

References

Feb 1, 1979·Analytical Biochemistry·G Ellman, H Lysko
Feb 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F CorralesJ M Mato
Dec 1, 1989·The American Journal of Clinical Nutrition·D L TribbleD Rudman
Oct 1, 1989·Alcoholism, Clinical and Experimental Research·R Hernández-MuñozC S Lieber
Jan 1, 1986·The Journal of Membrane Biology·S Bannai, N Tateishi
Oct 1, 1987·European Journal of Clinical Investigation·J M Burgunder, B H Lauterburg
Jan 1, 1974·Journal of Biochemistry·N TateishiY Sakamoto
Aug 1, 1973·The British Journal of Surgery·R N PughR Williams
Sep 26, 1980·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J D YoungJ C Ellory
Jan 1, 1983·Annual Review of Biochemistry·A Meister, M E Anderson
Jul 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B H LauterburgJ R Mitchell
Oct 1, 1981·Scandinavian Journal of Clinical and Laboratory Investigation·H E PoulsenP B Andreasen

❮ Previous
Next ❯

Citations

Jul 7, 1999·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·L GatéH Tapiero
Dec 25, 2002·Free Radical Biology & Medicine·Carmela Loguercio, Alessandro Federico
Jan 6, 2001·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C LoguercioC Del Vecchio Blanco
Dec 11, 1999·Alcoholism, Clinical and Experimental Research·C LoguercioC D Blanco
Jun 11, 2004·Annual Review of Nutrition·Siobhan E Moriarty-Craige, Dean P Jones
Feb 10, 2010·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Ding-zhu ShenPing Liu
Jul 22, 2008·Drug Metabolism Reviews·Dianne BottaTerrance J Kavanagh
Mar 21, 2007·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Naglaa El-Lakkany, Mona Nosseir
Jun 23, 2005·Immunobiology·Alessandro FedericoCarmela Loguercio
Feb 24, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Jinn-Tsyy LaiWen-Chuan Lin
Oct 2, 2014·Journal of Interpersonal Violence·Benjamin Bailey, Zvi Eisikovits
May 1, 2001·Current Protocols in Toxicology·C C WhiteT J Kavanagh
Dec 1, 1995·The Annals of Pharmacotherapy·B M Lomaestro, M Malone
Mar 19, 2021·Journal of Ayurveda and Integrative Medicine·Ananda Vardhan HebbaniVaradacharyulu NCh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.