Alteration of GABAergic neurotransmission by pulsed infrared laser stimulation.

Journal of Neuroscience Methods
Hua-Jun FengRobert L Macdonald

Abstract

Transient electrical impulses are conventionally used to elicit physiological responses in excitable tissues. While electrical stimulation has many advantages, it requires an electrode-tissue interface, exhibits relatively low spatial selectivity and always produces a "stimulus artifact". Recently, it has been shown that pulsed, low-energy infrared laser light can evoke nerve, muscle and sensory responses similar to those induced by traditional electrical stimulation in a contact-free, damage-free, artifact-free and spatially selective manner. However, the effect of transient infrared laser light on neurotransmission in the CNS is still largely unknown. Here, we tested the effect of infrared laser light on GABAergic neurotransmission. We recorded spontaneous inhibitory postsynaptic currents (sIPSCs) from cultured rat cortical neurons prior to and after infrared laser stimulation. Using transient infrared laser light, we either stimulated the neuronal soma that had axonal projections to the recorded neuron or directly stimulated the axons that projected to the recorded neuron. Optical stimulation led to enhanced amplitude, decreased decay time constant and increased frequency of sIPSCs. These alterations of sIPSC properties prod...Continue Reading

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Citations

Mar 29, 2014·Cell Calcium·Jonathan Matthew CayceAnita Mahadevan-Jansen
Apr 9, 2014·Hearing Research·Claus-Peter Richter, Xiaodong Tan
Jan 19, 2011·The Journal of Physiology·Suhrud M RajguruRichard D Rabbitt
Jul 9, 2013·Lasers in Surgery and Medicine·Rickard LiljemalmHans von Holst
Sep 3, 2013·NeuroImage·Jonathan M CayceAnna W Roe
May 7, 2016·Neuroscience and Biobehavioral Reviews·Lieven HuangJames A Bourne
Oct 3, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Wei DengPaul M Pilowsky
Jan 13, 2018·Scientific Reports·Xiaodong TanClaus-Peter Richter
Dec 20, 2019·Biomedical Optics Express·Xuedong ZhuMichelle Y Sander
Dec 19, 2016·Neurophotonics·Alex J WalshHope T Beier
May 18, 2021·Matter·Xiuying LiZhenpeng Qin
Feb 11, 2017··Bennett L. IbeyAlex J. Walsh

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