Alteration of GABAergic neurotransmission in Huntington's disease

CNS Neuroscience & Therapeutics
Maurice GarretJérôme Baufreton

Abstract

Hereditary Huntington's disease (HD) is characterized by cell dysfunction and death in the brain, leading to progressive cognitive, psychiatric, and motor impairments. Despite molecular and cellular descriptions of the effects of the HD mutation, no effective pharmacological treatment is yet available. In addition to well-established alterations of glutamatergic and dopaminergic neurotransmitter systems, it is becoming clear that the GABAergic systems are also impaired in HD. GABA is the major inhibitory neurotransmitter in the brain, and GABAergic neurotransmission has been postulated to be modified in many neurological and psychiatric diseases. In addition, GABAergic neurotransmission is the target of many drugs that are in wide clinical use. Here, we summarize data demonstrating the occurrence of alterations of GABAergic markers in the brain of HD carriers as well as in rodent models of the disease. In particular, we pinpoint HD-related changes in the expression of GABAA receptors (GABAA Rs). On the basis that a novel GABA pharmacology of GABAA Rs established with more selective drugs is emerging, we argue that clinical treatments acting specifically on GABAergic neurotransmission may be an appropriate strategy for improving...Continue Reading

References

Sep 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·H Möhler, T Okada
Nov 1, 1985·Journal of Neuropathology and Experimental Neurology·J P VonsattelE P Richardson
Jan 1, 1988·Southern Medical Journal·J T Stewart
Feb 15, 1973·The New England Journal of Medicine·T L PerryM Kloster
Sep 1, 1984·Neurology·F O WalkerI Shoulson
May 1, 1983·Neurology·N L FosterC A Tamminga
Oct 1, 1993·Brain : a Journal of Neurology·E Storey, M F Beal
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·T P BonnertP J Whiting
Jun 18, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·M CaraminsR J Trent
Oct 15, 2003·Trends in Molecular Medicine·Jia-Yi LiPatrik Brundin
Feb 26, 2004·Experimental Neurology·A Reiner
Apr 28, 2004·Trends in Neurosciences·Alexey SemyanovR Angus Silver
Aug 28, 2004·Trends in Neurosciences·Istvan Mody, Robert A Pearce
Oct 27, 2004·Journal of Neuroscience Research·Carlos CepedaMichael S Levine
Jan 7, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·A Jennifer MortonElizabeth S Maywood
Dec 27, 2005·Current Opinion in Pharmacology·Alan C Foster, John A Kemp
Sep 22, 2006·Human Molecular Genetics·Ruben SmithJia-Yi Li
May 15, 2007·Progress in Brain Research·J M TepperJ P Bolam
Jun 15, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ahmed R SadekJ Paul Bolam
Jul 20, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Patrick N PallierA Jennifer Morton
Oct 2, 2007·Trends in Neurosciences·Antonio PisaniD James Surmeier
Dec 22, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·J S PaulsenUNKNOWN Predict-HD Investigators and Coordinators of the Huntington Study Group
Sep 2, 2008·Neuropharmacology·Richard W Olsen, Werner Sieghart
Sep 20, 2008·Neuroscience Research·Mireille MassouhAndré Parent
Oct 24, 2008·Frontiers in Molecular Neuroscience·Jean-Marc Fritschy
Feb 10, 2009·Biological Psychiatry·Sven SchipplingMichael Orth
May 21, 2009·Expert Opinion on Emerging Drugs·Sarah L Mason, Roger A Barker
Oct 16, 2009·Journal of Neurology, Neurosurgery, and Psychiatry·Michael OrthJohn C Rothwell

❮ Previous
Next ❯

Citations

Mar 28, 2018·CNS Neuroscience & Therapeutics·Carlos Cepeda, Xiao-Ping Tong
Jul 25, 2018·CNS Neuroscience & Therapeutics·Xiao-Mei JiangXiao-Liang Wang
Aug 17, 2019·Journal of Neurochemistry·Erich E WankerSigrid Schnoegl
Jan 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Klaudia CybulskaMark Rijpkema
Dec 7, 2018·Open Biology·Yi-Ting HsuYijuang Chern
Sep 2, 2020·International Journal of Molecular Sciences·Rochelin DalanginRobert E Campbell
Dec 4, 2020·International Journal of Molecular Sciences·Katie AndrewsJinwei Zhang
Sep 23, 2019·Biological Psychiatry·Toshifumi TomodaAkira Sawa
May 29, 2021·RSC Medicinal Chemistry·Matteo BorginiPeter Wipf

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Neurology and Neuroscience Reports
Kara J WyantPraveen Dayalu
Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists
Kevin DuffJane S Paulsen
© 2022 Meta ULC. All rights reserved