Alteration of gonadotrophin and steroid hormone release, and of ovarian function by a GnRH antagonist in gilts

Animal Reproduction Science
K-P BrüssowG Nürnberg

Abstract

This study examined the impact of the gonadotrophin-releasing hormone (GnRH) antagonist Antarelix on LH, FSH, ovarian steroid hormone secretion, follicular development and pituitary response to LHRH in cycling gilts. Oestrous cycle of 24 Landrace gilts was synchronised with Regumate (for 15 days) followed by 800 IU PMSG 24h later. In experiment 1, Antarelix (n=6 gilts) was injected i.v. (0.5mg per injection) twice daily on four consecutive days from day 3 to 6 (day 0=last day of Regumate feeding). Control gilts (n=6) received saline. Blood was sampled daily, and every 20 min for 6h on days 2, 4, 6, 8 and 10. In experiment 2, gilts (n=12) were assigned to the following treatments: Antarelix; Antarelix + 50 microg LHRH on day 4; Antarelix + 150 microg LHRH on day 4 or control, 50 microg LHRH only on day 4. Blood samples were collected daily and every 20 min for 6h on days 2, 4 and 6 to assess LH pulsatility. Ovarian follicular development was evaluated at slaughter. Antarelix suppressed (P<0.05) serum LH concentrations. The amount of LH released on days 4-9 (experiment 1) was 8.80 versus 36.54 ngml(-1) (S.E.M.=6.54). The pattern of FSH, and the preovulatory oestradiol rise was not affected by GnRH antagonist. Suppression of LH re...Continue Reading

References

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Citations

Sep 10, 2005·Reproduction in Domestic Animals = Zuchthygiene·J KauffoldK-P Brüssow
Aug 17, 2005·Animal Reproduction Science·C A Herbert, T E Trigg
Mar 17, 2004·Reproduction, Fertility, and Development·J V VirolainenO A T Peltoniemi
May 26, 2018·Reproduction : the Official Journal of the Society for the Study of Fertility·Adam J ZiecikMonika M Kaczmarek
Apr 14, 2017·Porcine Health Management·Ellen de JongDominiek Maes
May 3, 2006·Theriogenology·Falk SchneiderCarsten Gründker

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