PMID: 9179452Apr 1, 1997Paper

Alteration of human sperm kinematics in cervical mucus due to nonoxynol-9

Contraception
E N Dunmire, David Katz

Abstract

Traditional endpoints of the double-ended test (DET), a contraceptive screening assay used to evaluate the ability of a compound to permeate cervical mucus and inhibit sperm progression, ignore important information about sublethal effects upon sperm cells. Improved contraceptive agents may capitalize on such sublethal aspects. This study utilized a DET testing protocol that included measurement of human sperm motion characteristics as an indicator of cell function within spermicide-exposed human mucus. The currently available spermicide nonoxynol-9 (N9) was used as the test compound and was dissolved in two different delivery solutions, deionized (DI) water and saline, to evaluate the effects of the osmolarity and pH of the delivery vehicle on test results. The N9-water treatment demonstrated significantly greater activity than the N9-saline treatment in terms of all measured variables, exhibiting an apparent "biopermeation" distance approximately 3 mm further into the mucus. The DI water control treatment displayed less activity than N9-saline in terms of the vanguard penetration distance, but comparable or greater activity in terms of inhibiting kinematic variables. The saline control treatment had no effect in terms of any ...Continue Reading

References

Jun 1, 1979·Biology of Reproduction·L J ZaneveldA K Bhattacharyya
Jan 1, 1992·The Journal of Infectious Diseases·S J Klebanoff
Apr 1, 1990·International Journal of Andrology·L RogbergA Pousette
Jan 1, 1980·Reproduction, Nutrition, Development·M L Kann, C Serres
Jul 23, 1981·Nature·P Y Tam, P Verdugo
Apr 1, 1994·Biology of Reproduction·E N Dunmire, D F Katz

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Citations

Jun 17, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·D H OwenD F Katz
Jan 2, 2009·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Vidya Iyer, S S Poddar
Jan 30, 1999·Applied and Environmental Microbiology·T TangheW Verstraete

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