Alteration of humoral and cellular immunity in manganese chloride-treated mice

Journal of Toxicology and Environmental Health
B SrisuchartR P Sharma


Immunological effects of manganese chloride (MnCl2) were determined in male CD-1 mice injected (ip) daily with MnCl2 (0, 1, 3, or 10 mg/kg) for 4 wk. Liver and spleen weights increased in the 10-mg/kg MnCl2 treatment group. The weights of thymus, kidney, and adrenal glands were not affected by MnCl2 treatment. No significant differences in peripheral erythrocyte or leukocyte counts were observed; however, packed cell volumes decreased in the medium- and high-dose groups. Manganese treatment significantly increased the uptake of [3H]thymidine (3H-TdR) by cultured splenic cells. The lymphoproliferative responses to phytohemagglutinin (PHA) and concanavalin A (Con A) increased at all levels of MnCl2 exposure. No differences in the responses to lipopolysaccharide (LPS) were observed. Mixed lymphocyte responses increased significantly with exposure to 10 mg MnCl2/kg. Another immunological alteration induced by MnCl2 was a dose-dependent immunosuppressive effect on the development of antibody-forming cells. The production of anti-sheep red blood cell antibody (alpha-SRBC) nearly ceased following exposure to 10 mg MnCl2/kg. This effect was apparently reversible, as the number of plaque-forming cells in the 10-mg/kg treatment group inc...Continue Reading


Nov 1, 1978·Toxicology and Applied Pharmacology·C L Gaworski, R P Sharma
May 31, 1979·Annals of the New York Academy of Sciences·R P Sharma, P J Gehring
Apr 1, 1978·Clinical Immunology and Immunopathology·A A Roman-FrancoG A Andres
Dec 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·J A CookD i Luzio NR
Jan 1, 1974·Methods in Enzymology·D J Hanahan, J E Ekholm
Apr 1, 1974·The Journal of Cell Biology·N A Berger, A M Skinner
Jun 4, 1971·Science·F E HemphillW B Buck
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·W S El-DeiryA G So
Aug 1, 1983·Toxicology and Applied Pharmacology·R R RogersR J Smialowicz
Jan 1, 1984·Journal of Interferon Research·N Hahon, J A Booth
Jan 1, 1984·Journal of Immunopharmacology·R J SmialowiczR J Garner
Aug 1, 1983·Acta Pharmacologica Et Toxicologica·S MagourI Steffen
Sep 1, 1980·Indian Journal of Pediatrics·N B Kumta, P R Sureka
Jul 1, 1958·Physiological Reviews·G C COTZIAS


Jan 1, 1988·Developmental and Comparative Immunology·M Cossarini-DunierV Guerin
Feb 7, 2008·The Cochrane Database of Systematic Reviews·C BennettJ Abbott
Feb 7, 2008·The Cochrane Database of Systematic Reviews·G MacdonaldJ Abbott
Oct 1, 1990·The Journal of Rural Health : Official Journal of the American Rural Health Association and the National Rural Health Care Association·L LawhorneH Tinker
Apr 12, 2020·Environmental Health : a Global Access Science Source·Barrett M WelchMolly L Kile
Jan 10, 2021·Seminars in Cell & Developmental Biology·Qian WuFudi Wang

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.