PMID: 2484731Oct 23, 1989Paper

Alteration of intrafusal bundle composition by nerve crush in neonatal rats

Neuroscience Letters
J Kucera, J M Walro

Abstract

We examined the expression of myosin heavy-chain isoforms in intrafusal muscle fibers of spindles formed in gastrocnemius muscles reinnervated in the presence of exogenous nerve growth factor after nerve crush in neonatal rats. Only 50% of the experimental spindles contained intrafusal fibers that expressed a slow-tonic myosin normally expressed by at least one fiber in every rat spindle. In addition, spindles containing only bag1 and/or chain fibers, but no bag2 fibers, were observed in reinnervated muscles whereas all normal spindles contain a bag2 fiber. These data suggest that afferents retain the capacity to induce the expression of a spindle-specific myosin in a period other than during normal development of intrafusal fibers. However, a scarcity of precursor cells available to become intrafusal fibers when contacted by afferents might have resulted in the alteration of intrafusal bundle composition in some spindles of reinnervated muscles.

References

Jan 1, 1989·Anatomy and Embryology·J Kucera, J M Walro
Jan 1, 1987·Anatomy and Embryology·J Kucera, J M Walro
Dec 1, 1988·The American Journal of Anatomy·J KuceraJ Reichler
Aug 1, 1973·The Journal of Comparative Neurology·J K Werner
Dec 1, 1982·The Journal of Cell Biology·D BaderD A Fischman
Oct 1, 1963·American Journal of Physical Medicine·E GUTMANN

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