PMID: 6405279Apr 28, 1983Paper

Alteration of leukotriene D4 hypotension by thyrotropin releasing hormone

Nature
W E LuxA I Faden

Abstract

Leukotriene D4 (LTD4), a component of slow reacting substance of anaphylaxis (SRS-A)1, produces marked hypotension in laboratory animals2,3, implicating it as a potential mediator of anaphylactic shock. It has been demonstrated that naloxone reverses the hypotension associated with endotoxaemia4-6, hypovolaemia7,8 and spinal injury9,10, presumably through blockade of endogenous opioid systems11. More recently, it has also been shown that thyrotropin releasing hormone (TRH) improves experimental shock12 and spinal injury13, and it has been postulated that TRH acts by 'physiological' antagonism of endogenous opioid systems in these conditions. Here we report that TRH both blocked and reversed leukotriene-induced hypotension in the unanaesthetized guinea pig, whereas naloxone had no effect. LTD4 hypotension was also reversed by intracerebroventricular (i.c.v.) administration of TRH at a dose that had no effect when given systemically. LTD4 administration was associated with sympatho-adrenomedullary activation, and TRH further augmented this response. Peripheral cholinergic blockade with methylatropine did not alter the leukotriene hypotension. These data demonstrate the first dissociation of TRH and naloxone in experimental shock ...Continue Reading

References

Jan 1, 1979·Progress in Neurobiology·G G Yarbrough
Oct 1, 1978·British Journal of Pharmacology·J R Fletcher, P W Ramwell
Jul 20, 1979·Science·A I Faden, J W Holaday
Oct 1, 1980·Journal of the Autonomic Nervous System·A I FadenJ W Holaday
Oct 29, 1981·The New England Journal of Medicine·A I FadenJ W Holaday
Nov 19, 1981·European Journal of Pharmacology·G FeuersteinI J Kopin
Jan 1, 1980·British Journal of Orthodontics·E T Clark
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J M DrazenE J Corey

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Citations

Jan 1, 1988·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·D Y HuL Li
Sep 1, 1988·Journal of Anesthesia·M MiyazakiT Mizobe
Sep 30, 1983·European Journal of Pharmacology·D J GoldsteinH R Keiser
May 1, 1984·Prostaglandins·G Feuerstein
Dec 1, 1984·Neuroscience Research·G FeuersteinA I Faden
Dec 27, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Bogdan StoicaAlan I Faden
Jul 22, 1999·Diabetes Research and Clinical Practice·H GulA Isimer
Feb 1, 1994·Clinical and Experimental Pharmacology & Physiology·D EvequozB Waeber
Jan 1, 1989·Annals of the New York Academy of Sciences·L O Koskinen
Jan 1, 1989·Annals of the New York Academy of Sciences·J W HoladayN J Gurll
Jan 1, 1989·Annals of the New York Academy of Sciences·A I FadenT K McIntosh
Jan 1, 1988·Annals of the New York Academy of Sciences·G MaroneC Vigorito
Apr 1, 1988·Annals of Emergency Medicine·R L MuellemanJ A Salomone
Jan 1, 1987·Central Nervous System Trauma : Journal of the American Paralysis Association·S K SalzmanA Winokur
Oct 12, 1999·The American Journal of Physiology·A I FadenA P Kozikowski
Jan 1, 1985·Central Nervous System Trauma : Journal of the American Paralysis Association·A I Faden
Jan 1, 1992·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·H AkdemirA Kurtsoy
Apr 1, 1985·Klinische Wochenschrift·M GoerigG Schettler

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Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.