Alteration of Liver Biomarkers in Patients with SARS-CoV-2 (COVID-19)

Journal of Inflammation Research
Pourya GholizadehHossein Samadi Kafil

Abstract

Coronavirus disease 2019 (COVID-19) emerged in China and spread worldwide. In this study, we assessed the characteristics of markers of the liver in patients with COVID-19 to provide new insights in improving clinical treatment. We recruited 279 patients who confirmed COVID-19 and the data of liver biomarkers and complete blood count of patients were defined as the day onset when the patients admitted to the hospital. The average of LDH value was 621.29 U/L in all patients with COVID-19, and CPK was 286.90 U/L. The average AST was 44.03 U/L in all patients, and ALT was 31.14 U/L. The AST/ALT ratio was 1.64 in all patients. The measurement of CRP was increased by 79.93% in all patients. Average ALT and AST values of patients with elevated ALT were significantly increased in comparison to patients with normal ALT (P-value = 0.001), while AST/ALT ratio was significantly decreased compared to patients with normal ALT (P-value= 0.014). In addition, the average LDH of patients with elevated ALT was significantly increased compared to patients with normal ALT (P-value = 0.014). Hepatic injury and abnormal liver enzymes related to COVID-19 infection is an acute non-specific inflammation alteration.

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Citations

Sep 8, 2020·Journal of Clinical Laboratory Analysis·Jinrui GaoZhihao Xu
Feb 16, 2021·World Journal of Gastroenterology : WJG·Halina Cichoż-Lach, Agata Michalak
Mar 14, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Felipe Ten-CatenHelder I Nakaya
Mar 25, 2021·Health Promotion Perspectives·Pourya GholizadehHossein Samadi Kafil
Jul 2, 2021·Clinical Case Reports·Shahram AhmadianHossein Samadi Kafil
Jul 3, 2021·International Journal of Environmental Research and Public Health·Do-Won KimChoong-Hee Park
Aug 18, 2021·International Journal of Biological Macromolecules·Hadis FathizadehHossein Samadi Kafil
Aug 27, 2021·World Journal of Clinical Cases·Gholam Reza SivandzadehKamran Bagheri Lankarani
Sep 26, 2021·Metallomics : Integrated Biometal Science·Haoxuan DingJie Feng

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