Alteration of local cerebral glucose utilization following intravenous administration of heroin in Fischer 344 rats

Brain Research
T J MartinL J Porrino

Abstract

The 2-deoxyglucose method was used to study the effects of acute administration of small intravenous doses of heroin on rates of glucose utilization in rat brain to identify small brain regions that may be involved in the acute behavioral effects of heroin. In contrast to previous studies which have used relatively large doses, the doses of heroin used in this study have been shown to be self-administered [Martin, T.J., Dworkin, S.I. and Smith, J.E., Alkylation of mu-opioid receptors by beta-funaltrexamine in vivo: comparison of the effects on in situ binding and heroin self-administration in rats., J. Pharmacol. Exp. Ther., 272 (1995) 1135-1140.]. Administration of 18 microg/kg of heroin resulted in higher rates of glucose utilization in the medial olfactory tubercle, anterior nucleus accumbens and dorsolateral caudate while having no other effects on limbic structures compared to saline-treated animals. Conversely, the rate of glucose utilization was lower than control in the habenula, dorsal raphe, and central gray following adminstration of 18 microg/kg of heroin. Administration of two higher doses (60 and 100 microg/kg) resulted in lower rates of glucose utilization in the thalamus, habenula, inferior colliculus, dorsal ra...Continue Reading

References

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Citations

Feb 11, 2012·Journal of Neurophysiology·L SheltonD Borsook
Sep 5, 2019·The Journal of Pharmacology and Experimental Therapeutics·Nathan P CoussensKurt Rasmussen
Oct 14, 2016·ACS Chemical Neuroscience·Ernesto SolisEugene A Kiyatkin

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