Alteration of mean platelet volume in the pathogenesis of acute ischemic stroke: cause or consequence?

Ideggyógyászati szemle
Zeynep Özözen Ayas, Ufuk Can

Abstract

Platelets have a crucial role on vascular disease which are involved in pathogenesis of ischemic stroke. Platelet size is measured as mean platelet volume (MPV) and is a marker of platelet activity. Platelets contain more dense granules as the size increases and produce more serotonin and tromboglobulin (b-TG) than small platelets. In this study, the alteration of MPV values were investigated in patients with acute stroke, who had MPV values before stroke, during acute ischemic stroke and 7 days after the stroke. The relationship between this alteration and risk factors, etiology and localization of ischemic stroke were also investigated. Sixty-seven patients with clinically and radiologically established diagnoses of ischemic stroke were enrolled into the study and stroke etiology was classified by modified Trial of Org 10 172 in Acute Stroke Treatment (TOAST) classification and, modified Bamford classification was used for localization and stroke risk factors were also evaluated. The platelet counts and MPV values from patient files in patients who had values before stroke (at examination for another diseases), within 24 hours of symptom onset and after 7 further days were analysed. MPV values increased after stroke (10.59±2....Continue Reading

Citations

Oct 14, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Katarzyna SzczeklikWirginia Krzyściak
Oct 28, 2019·Platelets·Farzaneh SadeghiAmir Houshang Shemirani

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