Alteration of metabolism of retinal taurine following prolonged light and dark adaptation: a quantitative comparison with gamma-aminobutyric acid (GABA)

Journal of Neuroscience Research
S IdaK Kuriyama

Abstract

Alteration of metabolism of taurine in prolonged light- and dark-adapted frog retinae were studied in comparison with that of gamma-aminobutyric acid (GABA) and the following results were obtained. (1) Statistically significant alterations in retinal taurine, an increase in dark-adapted, and a decrease in light-adapted states, respectively, occurred when frogs were adapted continuously to light or dark for more than 3 weeks. Under the same experimental conditions, no alteration in retinal GABA was noted. (2) At 3 weeks and thereafter, a significant increase of retinal cysteine sulfinic acid decarboxylase (CSD; EC 4.1.1.12) activity, an enzyme involved in the biosynthetic pathway of taurine, also occurred in the dark, whereas the activity in the light-adapted retina was reduced. On the other hand, the retinal activity of L-glutamate decarboxylase (GAD; EC 1.1.1.15), the rate-limiting enzyme of GABA biosynthesis, was not altered in dark- as well as light-adapted state. Similarly, retinal GABA-transaminase (GABA-T; EC 2.6.1.19)-succinic semialdehyde dehydrogenase (SSADH; EC 1.2.1.16) was unaltered. (3) These alterations in retinal taurine were, however, unaccompanied by any changes in factors related to transmitter actions such as...Continue Reading

References

Jan 1, 1976·Life Sciences·R L MathurP Mandel
Sep 15, 1979·Biochemical Pharmacology·H TokunagaK Kuriyama
Feb 1, 1975·Life Sciences·R M Di GiorgioS Macaione
Mar 1, 1976·Journal of Neurochemistry·H T OrrO H Lowry
Oct 8, 1976·Brain Research·S J Enna, S H Snyder
Jul 1, 1976·Journal of Neurochemistry·A J Kennedy, M J Voaden
Nov 1, 1974·Journal of Neurochemistry·A J Kennedy, M J Voaden
Mar 15, 1973·Brain Research·H Pasantes-MoralesP Mandel
Sep 14, 1973·Brain Research·M S Starr
Jan 28, 1972·Brain Research·L T Graham
Jan 20, 1967·Science·J E Dowling
May 1, 1980·Journal of Neurochemistry·A M López-Colomé, H Pasantes-Morales

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Citations

May 1, 1991·Brain Research. Brain Research Reviews·J B Lombardini
Jan 1, 1989·Progress in Neurobiology·R J Huxtable
Apr 12, 2014·Progress in Retinal and Eye Research·Nicolas FrogerSerge Picaud
Jan 1, 1983·Journal of Neuroscience Research·C NishimuraK Kuriyama

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