Alteration of neuropathic and visceral pain in female C57BL/6J mice lacking the PPAR-α gene.

Psychopharmacology
Jessica Ruiz-MedinaEmilio Fernandez-Espejo

Abstract

Peroxisome proliferator-activated receptors (PPARs) participate in the control of chronic neuropathic and inflammatory pain, and these receptors could play a role on acute pain. We used null (PPAR-α -/-) and wild-type female mice and the PPAR-α blocker GW6471 to evaluate (1) the role of PPAR-α on neuropathic pain, (2) the involvement of PPAR-α on visceral and acute thermal nociception, and (3) tissue levels of pro-inflammatory factors. Neuropathic pain was induced by sciatic nerve ligature. Acute thermal nociception was evaluated through hot-plate, tail-immersion, and writhing tests. The pro-inflammatory factors nitric oxide, TNF-α, and interleukins-1β and -3 were measured. Regarding neuropathic pain, higher sensitivity to thermal and mechanical non-noxious and noxious stimuli was observed in mice lacking PPAR-α. Cold and mechanical allodynia and heat hyperalgesia were augmented in null mice. With respect to visceral nociception, writhes after acetic acid were enhanced in mutant mice. Although basal thermal sensitivity was enhanced in PPAR-α -/- mice, cutaneous thermal nociception did not differ between genotypes. Blockade of PPAR-α was devoid of effects on acute thermal and writhing tests. Finally, nerve ligature enhanced pro-...Continue Reading

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Citations

Sep 14, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Iryna A KhasabovaVirginia Seybold
Jan 30, 2014·Nature Neuroscience·Daniele Piomelli, Oscar Sasso
Nov 13, 2013·ASN Neuro·Shweta Mandrekar-ColucciDana M McTigue
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Feb 24, 2015·PPAR Research·Elizabeth P Moran, Jian-Xing Ma
Nov 4, 2016·Neurochemical Research·Hui XuZhikai Gu
Apr 22, 2018·British Journal of Pharmacology·Bright N OkineDavid P Finn
Oct 22, 2019·Biochimica Et Biophysica Acta. Molecular Basis of Disease·I A M van ThielJ Seppen
Jun 19, 2018·Scandinavian Journal of Pain·Rashid GiniatullinPasi Tavi

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