Alteration of nitrergic neuromuscular transmission as a result of acute experimental colitis in rat.

Journal of Veterinary Science
Tae-Sik SungIl-Suk Yang

Abstract

Nitric oxide (NO) is a non-adrenergic, non-cholinergic neurotransmitter found in the enteric nervous system that plays a role in a variety of enteropathies, including inflammatory bowel disease. Alteration of nitrergic neurons has been reported to be dependent on the manner by which inflammation is caused. However, this observed alteration has not been reported with acetic acid-induced colitis. Therefore, the purpose of the current study was to investigate changes in nitrergic neuromuscular transmission in experimental colitis in a rat model. Distal colitis was induced by intracolonic administration of 4 % acetic acid in the rat. Animals were sacrificed at 4 h and 48 h postacetic acid treatment. Myeloperoxidase activity was significantly increased in the acetic acid-treated groups. However, the response to 60 mM KCl was not significantly different in the three groups studied. The amplitude of phasic contractions was increased by Nomega-nitro-L-arginine methyl ester (L-NAME) in the normal control group, but not in the acetic acid-treated groups. Spontaneous contractions disappeared during electrical field stimulation (EFS) in normal group. However, for the colitis groups, these contractions initially disappeared, and then reappe...Continue Reading

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Citations

Jun 17, 2011·World Journal of Gastroenterology : WJG·Chun-Jie LiuXiao-Qin Ha
May 31, 2012·World Journal of Diabetes·Mária Bagyánszki, Nikolett Bódi
Nov 10, 2015·BioMed Research International·Takahiko ShiinaYasutake Shimizu
Dec 30, 2014·Journal of Neurogastroenterology and Motility·Jae Hyung ParkKyung Sik Park
Jun 19, 2008·The American Journal of Gastroenterology·Monica FaccoGiovanni Zaninotto
May 18, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·John H WinstonSushil K Sarna

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