Alteration of nociceptive integration in the spinal cord of a rat model of Parkinson's disease

Movement Disorders : Official Journal of the Movement Disorder Society
Keri-Ann CharlesAbdelhamid Benazzouz

Abstract

Pain is a major non motor symptom that contributes to impaired quality of life in PD. However, its mechanism is unknown. We sought to identify the pain phenotypes and parallel changes in spinal integration of peripheral stimuli in a rat model of PD induced by lesions of SN dopamine neurons, using behavioral plantar and von Frey tests as well as electrophysiology of the dorsal horn. We show that dopamine depletion by 6-OHDA induced hypersensitivity to mechanical and thermal stimuli. These abnormal behaviors were paralleled by increased neuronal responses and hyperexcitability of wide dynamic range neurons of lamina V of the dorsal horn of the spinal cord in response to electrical stimulation of the sciatic nerve in the 6-OHDA model as compared to sham rats. These results provide evidence for alteration of nociceptive integration in the spinal dorsal horn neurons in 6-OHDA rats that can reflect changes in pain behavior. © 2018 International Parkinson and Movement Disorder Society.

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Citations

Jul 2, 2019·Current Opinion in Neurology·Katarina RukavinaKallol Ray Chaudhuri
Apr 24, 2020·Frontiers in Pharmacology·Elena Paredes-RodriguezCristina Miguelez
Oct 27, 2018·Neuroscience and Biobehavioral Reviews·Fanny FaivreMichel Barrot
Feb 6, 2021·Brain Sciences·Amit AbrahamGammon M Earhart
Jul 12, 2021·Neuropharmacology·Airam Nicole Vivanco-EstelaGlauce C do Nascimento

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