Alteration of nuclear factor-kappaB pathway promote neuroinflammation depending on the functions of estrogen receptors in substantia nigra after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment

Neuroscience Letters
S MitraA Bhattacharyya

Abstract

The simultaneous role of neuroprotective estrogen and neurodegenerative inflammation during the progression of Parkinson's disease (PD) is still remaining elusive. The novel importance of the present study in MPTP mediated mouse model of Parkinson's disease (PD) is-to investigate the status of neuronal and glial cells in a time chase experiment; to explore which pathway of NF-kappaB exist to proceed the neuroinflammation; to investigate the status of estrogen and the activation pattern of nuclear or cytosolic estrogen receptors in either sexes of Swiss albino mice during MPTP mediated progressive neurodegeneration in the substantia nigra. After MPTP intoxication, the nigral molecular anatomy was changed differently in separate time interval during the progression of neurodegeneration with/without association of glial cells and functional (via its nuclear and cytosolic receptors) estrogen level. Both the canonical and/or non-canonical pathways of NF-kappaB exist in the substantia nigra of both the sexes after MPTP treatment that is why inspite of presence of estrogen, neuroinflammation progresses. The homodimeric or heterodimeric form of ER-beta binds with NF-kappaB molecules p65 and RelB differently, but the canonical or non-ca...Continue Reading

References

Jun 5, 2004·Parkinsonism & Related Disorders·Lisa M Shulman
Apr 3, 2007·Nature Protocols·Vernice Jackson-Lewis, Serge Przedborski
Jun 16, 2009·Journal of Inflammation·Subhadip KunduArindam Bhattacharyya
Oct 1, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Phillip M Rappold, Kim Tieu

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Citations

Aug 11, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yebo ZhouJin-Song Bian
Mar 31, 2017·Molecular Neurobiology·Rosalba SiracusaEmanuela Esposito
Jun 2, 2018·Journal of Immunology Research·Yazmin M Flores-MartinezDaniel Martinez-Fong
Sep 26, 2019·Neural Regeneration Research·Rachel KeryGregory W Kirschen
Jul 3, 2021·Cells·Karli MockenhauptTomasz Kordula

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