Alteration of processing induced by a single nucleotide polymorphism in pri-miR-126.

Biochemical and Biophysical Research Communications
Ratanakanit HarnprasopwatAi Kotani

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that inhibit expression of specific target genes at the post-transcriptional level. Sequence variations in miRNA genes, including pri-miRNAs, pre-miRNAs and mature miRNAs, could potentially influence the processing and/or target selection of miRNAs. In this study, we have found the single nucleotide polymorphism (SNP) at the twenty-fourth nucleotide (+24) of the mature miR-126 in the genome of RS4;11 cells, derived from a MLL-AF4 ALL patient. Through a series of in vivo analyzes, we found that this miR-126 SNP significantly blocks the processing of pri-miRNA to mature miRNA, as well as reduces miRNA-mediated translational suppression. Moreover, its frequency is different among races. Thus, our study emphasizes the importance of identifying new miRNA SNP and its contribution to miRNA biogenesis which is possible link to human genetic disease.

References

Jun 26, 2003·Nucleic Acids Research·Michael Zuker
Sep 26, 2003·Nature·Yoontae LeeV Narry Kim
Dec 6, 2003·Science·Chang-Zheng ChenDavid P Bartel
Apr 24, 2004·Science·Soraya YektaDavid P Bartel
Sep 17, 2004·Nature·Victor Ambros
Dec 3, 2004·Genes & Development·Jinju HanV Narry Kim
May 11, 2005·Biochemical and Biophysical Research Communications·Naoharu Iwai, Hiroaki Naraba
Jun 10, 2005·Nature·Jun LuTodd R Golub
Jul 29, 2005·Nature·Andy J MinnJoan Massagué
Aug 6, 2005·Science·Ramesh S PillaiWitold Filipowicz
Aug 27, 2005·Cell·Shveta BaggaAmy E Pasquinelli
Oct 28, 2005·The New England Journal of Medicine·George Adrian CalinCarlo M Croce
Jan 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Tamia A HarrisCharles J Lowenstein
Jul 8, 2008·Biochemical and Biophysical Research Communications·M CrawfordS P Nana-Sinkam
Aug 13, 2008·Developmental Cell·Shusheng WangEric N Olson
Oct 7, 2008·Biochemical and Biophysical Research Communications·Jin ZhangDuan Ma
Jan 1, 2009·Biochemical and Biophysical Research Communications·Yoshimasa SaitoGangning Liang

❮ Previous
Next ❯

Citations

Jun 4, 2013·Annals of Hematology·Leonidas Benetatos, George Vartholomatos
Jul 31, 2013·Proceedings of the National Academy of Sciences of the United States of America·Kazuki OkuyamaAi Kotani
Jan 29, 2013·Cellular and Molecular Life Sciences : CMLS·Valentina LibriAmy H Buck
Jun 5, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Joon Seol BaeHyoung Doo Shin
Sep 19, 2015·Nucleic Acids Research·Sophia CammaertsPeter De Rijk
Feb 11, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Huanhuan ZhaoZhengmao Zhu
Jun 9, 2015·Genome Génome / Conseil National De Recherches Canada·Shan-He WangXiang-Tao Kang
May 30, 2014·Molecular Therapy : the Journal of the American Society of Gene Therapy·Maria ChiriacoAlessandro Aiuti
Apr 17, 2018·Bioscience, Biotechnology, and Biochemistry·Jie ChaiZongyi Guo
Dec 10, 2015·Circulation Research·Dorothee KaudewitzManuel Mayr
Aug 1, 2013·Biomolecular Concepts·Jesús García-LópezJesús Del Mazo
Mar 10, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Neda SepahiElahe Nimi Hoveidi
Jan 27, 2015·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Annie K McAuleyAlex W Hewitt

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.