Alteration of proteins expression in apoptotic FL cells induced by MCLR

Environmental Toxicology
Ming-Luan XingLi-hong Xu

Abstract

Microcystins (MCs) are a family of monocyclic heptapeptide hepatotoxins produced by freshwater species of cyanobacteria. Microcystin-LR (MCLR) is the most frequently studied and most toxic in over 80 MC congeners. Great deals of studies have demonstrated that MCLR can induce apoptosis in a wide variety of cell types. Although much evidence indicates that mitochondria play a pivotal role in MCLR-induced apoptosis, the complicated apoptosis mechanisms induced by MCLR have not been completely characterized. It is possible that there are other apoptotic pathways existing in MCLR-induced apoptosis. The present study was undertaken to determine the expression of PP2A, CHOP, Bax, Bcl-2, and p53 proteins in MCLR-induced apoptosis in FL cells. The results showed that MCLR could induce apoptosis in FL cells and the process was accompanied with the upregulation of PP2A, Bax, and p53 proteins and the downregulation of Bcl-2 proteins. In addition, the CHOP protein was upregulated at most treatment groups and decreased at the highest concentration group. These results, especially the alteration of PP2A and CHOP proteins might provide new insights into MCLR-induced apoptosis.

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Citations

Apr 24, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tan LiLihong Xu
Feb 18, 2010·International Journal of Molecular Sciences·Alexandre Campos, Vitor Vasconcelos
Jun 24, 2011·International Journal of Biological Sciences·Tan LiLihong Xu
Nov 26, 2015·International Journal of Molecular Sciences·Fei CaiJianghua Wang
Aug 3, 2010·Toxicon : Official Journal of the International Society on Toxinology·Wendi QinLiuyan Yang
Jul 2, 2008·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Yanyan ZhaoDapeng Li
Nov 2, 2015·Journal of Hazardous Materials·Liang ChenPing Xie
Apr 29, 2015·Journal of Biochemical and Molecular Toxicology·Junguo MaXiaoyu Li
Dec 3, 2011·Journal of Zhejiang University. Science. B·Jing LiangLi-Hong Xu
May 20, 2015·Toxicon : Official Journal of the International Society on Toxinology·Mi ZhouJin Xu
Mar 3, 2010·Environmental Toxicology·Pu HuangLi-Hong Xu
Mar 25, 2017·Environmental Pollution·Junguo MaXiaoyu Li

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