PMID: 3763438Jul 1, 1986Paper

Alteration of secretin-stimulated cardiac adenylate cyclase activity in rats with portacaval shunt

Peptides
S De FontaineJ Christophe

Abstract

Wistar rats were submitted to portacaval anastomosis (PCA). Control rats were sham-operated and pair-fed (SOPF). After 3 weeks, PCA led to the hypertrophy of right atrium (+50%), left atrium (+67%) and both ventricles (+26%). The response of adenylate cyclase activity to secretin was specifically and markedly decreased in membranes from atria (-51 to 59%) and ventricles (-68 to 69%). These data suggest a decrease in the number of functional secretin receptors in heart considering that: the half-maximal stimulatory secretin concentration was unchanged; glucagon stimulations were unaltered and D,L-isoproterenol stimulations were hardly affected; the Gpp(NH)p-, NaF-, and forskolin-stimulated adenylate cyclase activities were moderately decreased (in ventricles, by 14-28%) or unchanged (in atria).

References

Oct 1, 1979·The American Journal of Clinical Nutrition·R van Hoorn-HickmanW A van Hoorn
Nov 1, 1979·Proceedings of the Society for Experimental Biology and Medicine·P G JustusB E Kolts
Aug 1, 1985·Biological Chemistry Hoppe-Seyler·B WittigK Jungermann
Apr 1, 1974·Analytical Biochemistry·Y SalomonM Rodbell
Dec 1, 1983·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·P ChatelainJ Christophe
Apr 1, 1981·Pflügers Archiv : European journal of physiology·P ChatelainJ Christophe
Aug 1, 1983·Pflügers Archiv : European journal of physiology·P RobberechtJ Christophe
May 1, 1984·Pflügers Archiv : European journal of physiology·P RobberechtJ Christophe
Dec 1, 1980·The Journal of Clinical Endocrinology and Metabolism·W J KalkL A Van der Walt
Jun 1, 1983·The Journal of Trauma·M K McLeodD S Gann
Dec 1, 1980·Pflügers Archiv : European journal of physiology·P ChatelainJ Christophe

❮ Previous
Next ❯

Citations

Dec 1, 1988·Digestive Diseases and Sciences·T MineE Ogata
May 27, 2010·Journal of Endocrinological Investigation·D H St-Pierre, F Broglio
Aug 26, 2006·Regulatory Peptides·Francis K Y SiuBilly K C Chow

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.