Alteration of serotonin release in the guinea pig orbito-frontal cortex by selective serotonin reuptake inhibitors. Relevance to treatment of obsessive-compulsive disorder

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
M el MansariP Blier

Abstract

Potent serotonin (5-HT) reuptake inhibitors are the only antidepressant agents thus far shown to be effective in the treatment of obsessive-compulsive disorder (OCD). Positron emission tomography studies in humans have implicated the orbito-frontal cortex and the head of caudate nucleus in the mediation of OCD symptoms. Since the delay of the maximal therapeutic effect of selective 5-HT reuptake inhibitors (SSRI) is longer in OCD than in major depression and the terminal 5-HT autoreceptor is not desensitized in the guinea pig frontal cortex after 3 weeks of SSRI administration, the effects of the SSRI paroxetine (10 mg/kg/day) and fluoxetine (5 mg/kg/day) on 5-HT release and on the sensitivity of the terminal 5-HT autoreceptor were investigated in the guinea pig frontal cortex, the orbito-frontal cortex, and the head of caudate nucleus following a washout period after 3 and 8 weeks of treatment. In preloaded slices prepared from guinea pigs treated with paroxetine for 3 weeks, the electrically evoked release of [3H]5-HT release was enhanced in the frontal cortex (21%) but not in the orbito-frontal cortex or in the head of caudate nucleus. However, after an 8-week treatment, the evoked release of [3H]5-HT was significantly enhan...Continue Reading

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Citations

Apr 1, 1996·Psychopharmacology·Y K WingP J Cowen
Feb 1, 2002·European Journal of Pharmacology·Maxime RicherPierre Blier
Sep 21, 2002·Lancet·Dan J Stein
Jun 29, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·E DremencovM E Newman
Mar 26, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Sîan M J HemmingsDan J Stein
Mar 12, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Christine LochnerDan J Stein
Sep 18, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Benjamin D GreenbergSuzanne N Haber
Oct 28, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marcelo Queiroz HoexterGeraldo Filho Busatto
May 10, 2000·Clinical Neuropharmacology·B H Harvey, C D Bouwer
Sep 15, 2000·Journal of the American Academy of Child and Adolescent Psychiatry·D R RosenbergG J Moore
Feb 3, 1999·Annals of the New York Academy of Sciences·P BlierC de Montigny
Apr 11, 2001·Journal of Clinical Child Psychology·M A Grados, M A Riddle
Jun 12, 2012·Expert Opinion on Drug Discovery·Sonia Torres-SanchezEsther Berrocoso
Jan 18, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Claire M GillanGuido van Wingen
Jun 5, 2003·Expert Opinion on Investigational Drugs·Joyce Davidson, Throstur Bjorgvinsson
Mar 7, 2006·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Ying QuStanley I Rapoport
Jan 6, 2001·Neuron·A M Graybiel, S L Rauch
Mar 19, 2014·Neuroscience and Biobehavioral Reviews·Cedric B P MartinRaymond Mongeau
Jul 31, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Marcelo Q HoexterEuripedes C Miguel
Mar 20, 2003·Psychopharmacology·Lotte de GrooteHerman G M Westenberg
Oct 24, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Georg JuckelDan Rujescu
Jan 1, 2007·International Journal of Psychiatry in Clinical Practice·Pierre Blier, Mostafa El Mansari
Sep 24, 2004·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Susan L Andersen, Carryl P Navalta
Apr 4, 2000·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·L Baving, M H Schmidt
Jul 15, 2006·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Pierre BlierMartine F Flament

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