Alteration of specific cytokine expression patterns in patients with breast cancer

Scientific Reports
Kosuke KawaguchiMasakazu Toi

Abstract

Systemic inflammation has been associated with aggressive tumor growth, invasion, and metastasis. Here we performed a comprehensive analysis of 26 kinds of inflammatory cytokine expression patterns among 185 patients with breast cancer and 54 healthy volunteers followed by chemometric analysis. We identified the specific cytokine expression patterns of breast cancer patients compared to healthy volunteers with (1) VEGF, IL-9, GM-CSF, IL-13, IL-4, and IFNγ, (2) IL-8, IL-10, IL-12, IL-5, IL-7, IL-1α, GCSF, IL-1β, and TNFα and (3) IL-2, Eotaxin, MIP1β, MIP1α, IL-17, and bFGF. Among the patients with breast cancer, we identified the specific cytokine signature of metastatic patients compared to non-metastatic patients. We also established a mathematical model for distinguishing patients with breast cancer from healthy volunteers and metastatic patients from non-metastatic patients. This cytokine network analysis could provide new insights into early intervention and effective therapeutic strategy for patients with breast cancer.

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Citations

Nov 9, 2019·NPJ Breast Cancer·Margaret E Gatti-MaysElizabeth A Mittendorf
Dec 11, 2019·BMC Medicine·Amir Abbas Momtazi-BorojeniAmirhossein Sahebkar
May 3, 2020·Journal of Experimental & Clinical Cancer Research : CR·Somshuvra BhattacharyaPilar de la Puente
Jun 6, 2020·Games for Health Journal·Ricardo da Silva AlvesLeonardo César Carvalho
Mar 7, 2021·Hormone Molecular Biology and Clinical Investigation·Mohammad Reza ShiranMohsen Rashidi
Mar 15, 2021·Trends in Immunology·Jee Hye KangArabella Young
Apr 4, 2021·International Journal of Molecular Sciences·Jingwei ShiMarko Kornmann
Apr 4, 2021·Vaccines·Marco Carlo MerlanoOrnella Garrone
May 9, 2021·Cancer Metastasis Reviews·Molly A NelsonWassana Yantasee
May 23, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sreya DasRahul Purwar
Jul 27, 2021·Frontiers in Oncology·Apriliana E R KartikasariMagdalena Plebanski
Jun 4, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Todd P WhiteheadCatherine Metayer
Sep 11, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Nanna JørgensenThomas Vauvert F Hviid

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Methods Mentioned

BETA
PCA
biopsy
irradiate
RNA-seq

Software Mentioned

R
OPLS
SPSS
DA
R ropls package
OPLDS

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