Alteration of TH1 and TH2 cells by intracellular cytokine detection in patients with unexplained recurrent abortion before and after immunotherapy with the husband's mononuclear cells

Fertility and Sterility
Tomokazu YokooKenichi Tanaka

Abstract

To elucidate the possible mechanisms of immunotherapy for unexplained recurrent aborters using their husband's mononuclear cells. Prospective clinical study. Institutional practice at the Outpatient Clinic for Infertility, Niigata University Medical Hospital. Fifty-two unexplained recurrent aborters were chosen as an experimental group. Each patient was injected with her husband's mononuclear cells as immunotherapy. Peripheral blood was obtained from the patients. The percentage of CD4-positive cells, TH1 cells, TH2 cells, and the TH1/TH2 ratio were analyzed in the patients before and after immunotherapy. The same analyses were performed in the successful and the unsuccessful group. To date, 42 of the 52 patients have become newly pregnant. Of the 42, 34 patients have already delivered (successful group) and 3 are now pregnant, while the remaining 8 cases experienced repeated abortion (unsuccessful group). The percentage of TH2 cells significantly increased in the total patient population, while the TH1/TH2 ratio significantly decreased in the total patient population and in the successful group. These findings suggest that immunotherapy with the husband's mononuclear cells for unexplained recurrent abortion induces a dominant ...Continue Reading

References

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Citations

Nov 15, 2012·Journal of Translational Medicine·Ida ContastaAnna Maria Berghella
Oct 2, 2013·Journal of Human Reproductive Sciences·Ahad ZareMaryam Nourizadeh
Nov 14, 2007·American Journal of Reproductive Immunology : AJRI·Taro NonakaKenichi Tanaka
Feb 16, 2008·American Journal of Reproductive Immunology : AJRI·Behrouz Gharesi-FardEskandar Kamali-Sarvestani
Apr 6, 2011·American Journal of Reproductive Immunology : AJRI·Petra HorkáMarta Kalousová
Mar 25, 2010·American Journal of Reproductive Immunology : AJRI·Nasim KheshtchinAbbas Rezaei
Jul 10, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Marcelo Borges CavalcanteRicardo Barini
Feb 12, 2013·Journal of Reproductive Immunology·Behrouz Gharesi-FardHossein Haghbin
Apr 1, 2018·American Journal of Reproductive Immunology : AJRI·Hamed HajipourMohammad Nouri
Dec 23, 2016·Archives of Gynecology and Obstetrics·Marcelo Borges CavalcanteRicardo Barini
Sep 4, 2012·Molecular Medicine Reports·Jing XiaoJing Xiong
Dec 21, 2017·Reproductive Medicine and Biology·Koji NakagawaKoushi Yamaguchi
Mar 9, 2021·Dermatologic Therapy·Roberto RussoAurora Parodi
Jun 9, 2021·Immunity, Inflammation and Disease·Sudong LiuRuiqiang Weng
Jul 13, 2007·Current Opinion in Obstetrics & Gynecology

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