Alteration of the timing of implantation by in vivo gene transfer: delay of implantation by suppression of nuclear factor kappaB activity and partial rescue by leukemia inhibitory factor

Biochemical and Biophysical Research Communications
Hitomi NakamuraYuji Murata

Abstract

Nuclear factor kappaB (NF-kappaB) is activated in the murine endometrium during implantation period [Am. J. Reprod. Immunol. 51 (2004) 16]. Transient transfection of IkappaBalpha mutant (IkappaBalphaM) cDNA into the mouse uterine cavity using hemagglutinating virus of Japan envelope vector suppressed uterine NF-kappaB activity less than half of that observed in control on days 3.5 and 4.5 p.c. IkappaBalphaM cDNA transfection led to significant delay of implantation. After IkappaBalphaM cDNA transfection, LIF mRNA expression in the uterus was significantly suppressed on days 3.5 and 4.5 p.c. Co-transfection of LIF cDNA with IkappaBalphaM cDNA in the uterus partially rescued the delay of implantation induced by suppression of NF-kappaB activity. Taken together, these findings indicate that NF-kappaB activation determines the timing of the implantation, at least in part, via control of LIF expression.

References

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Jan 17, 2004·American Journal of Reproductive Immunology : AJRI·Hitomi NakamuraYuji Murata

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Citations

Feb 19, 2008·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Mingmin ZhangJinjin Zhang
Apr 30, 2010·Reproductive Biology and Endocrinology : RB&E·Jason W RossRodney D Geisert
Aug 4, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Stefan BauersachsEckhard Wolf
Dec 2, 2014·Journal of Animal Science and Biotechnology·Rodney D GeisertDaniel J Mathew
Nov 22, 2007·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Pranab Lal Pakrasi, Anil K Jain
Mar 24, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Daniel MathewRodney Geisert
Aug 23, 2005·Journal of Reproductive Immunology·Tadashi KimuraYuji Murata
Feb 21, 2018·BJOG : an International Journal of Obstetrics and Gynaecology·A Sakowicz
Sep 29, 2018·American Journal of Reproductive Immunology : AJRI·Zuzanna KunickaIwona Bogacka
Jul 12, 2020·Reproductive Sciences·Can ZhuJi-Long Liu
Jan 16, 2021·International Journal of Molecular Sciences·Maciej W SochaMichał Wiciński

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