PMID: 6103735Jun 9, 1980Paper

Alteration of tyrosine hydroxylase activity in the locus coeruleus after administration of p-chlorophenylalanine

Brain Research
F CrespiJ F Pujol

Abstract

The time course of the variations in tyrosine hydroxylase activity (THA) and serotonin (5-HT) content were measured in the rat locus coeruleus after parachlorophenylalanine (PCPA) administration. Highly significant decreases in the 5-HT content in LC were found 24-48 h after PCPA treatment (300 mg/kg daily). An increase in THA (in the LC) was found to be significant 4 days after 2 successive injections of PCPA and after 4 successive injections of the drug THA gradually increased, reaching a maximum around 4 days after the last injection. This maximum increase in THA was greatly reduced when 5-HTP was simultaneously administered with PCPA. These results join others which suggest that a serotonin-mediated mechanism could be one of the processes controlling noradrenaline metabolism in the locus coeruleus.

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Citations

Jan 1, 1990·Synapse·E H Cook
Jan 1, 1994·Journal of Neural Transmission. General Section·C J Clayton, R E Hicks
Jan 1, 1991·Psychopharmacology·W J McEntee, T H Crook
Jan 1, 1984·Neuroscience and Biobehavioral Reviews·Z AmitS O Ogren
Aug 1, 1996·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·J Harro, L Oreland
Jun 18, 2002·European Journal of Pharmacology·Olga L PudovkinaBen H C Westerink
Dec 1, 1990·The Japanese Journal of Psychiatry and Neurology·T KomoriI Kitayama
Jun 9, 1998·Annals of the New York Academy of Sciences·G A Ordway
Oct 22, 2009·Pflügers Archiv : European journal of physiology·Vanessa de Souza MorenoLuciane H Gargaglioni
Feb 24, 2009·Journal of Psychiatric Research·Christa HercherNaguib Mechawar
Sep 30, 1982·Brain Research·F Crespi, M Jouvet
Apr 30, 2010·The International Journal of Neuropsychopharmacology·Cristina MiguelezLuisa Ugedo
Nov 1, 1988·Journal of Neurochemistry·R LabatutJ F Pujol
Jan 1, 1997·Archives of Physical Medicine and Rehabilitation·G A Mellick, L B Mellick

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