Alteration to hippocampal volume and shape confined to cannabis dependence: a multi-site study

Addiction Biology
Yann ChyeNadia Solowij

Abstract

Cannabis use is highly prevalent and often considered to be relatively harmless. Nonetheless, a subset of regular cannabis users may develop dependence, experiencing poorer quality of life and greater mental health problems relative to non-dependent users. The neuroanatomy characterizing cannabis use versus dependence is poorly understood. We aimed to delineate the contributing role of cannabis use and dependence on morphology of the hippocampus, one of the most consistently altered brain regions in cannabis users, in a large multi-site dataset aggregated across four research sites. We compared hippocampal volume and vertex-level hippocampal shape differences (1) between 121 non-using controls and 140 cannabis users; (2) between 106 controls, 50 non-dependent users and 70 dependent users; and (3) between a subset of 41 controls, 41 non-dependent users and 41 dependent users, matched on sample characteristics and cannabis use pattern (onset age and dosage). Cannabis users did not differ from controls in hippocampal volume or shape. However, cannabis-dependent users had significantly smaller right and left hippocampi relative to controls and non-dependent users, irrespective of cannabis dosage. Shape analysis indicated localized ...Continue Reading

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Citations

Jul 13, 2019·The Australian and New Zealand Journal of Psychiatry·Valentina LorenzettiNadia Solowij
Aug 14, 2019·Addiction·Emese KroonJanna Cousijn
Nov 7, 2019·Molecular Psychiatry·Peter ManzaNora D Volkow
Feb 2, 2019·European Archives of Psychiatry and Clinical Neuroscience·Valentina LorenzettiCarl A Roberts
Feb 23, 2020·Frontiers in Behavioral Neuroscience·Cristina E María-Ríos, Jonathan D Morrow
Feb 15, 2020·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Javier Fernández-RuizManuel Guzmán
Jun 1, 2021·Frontiers in Psychiatry·Katherine L McPhersonNora D Volkow
Nov 30, 2020·The Annals of Thoracic Surgery·Amber FamigliettiPuja Gaur Khaitan

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