Alterations in arterial CO2 rather than pH affect the kinetics of neurovascular coupling in humans.

The Journal of Physiology
Hannah G CaldwellPhilip N Ainslie

Abstract

We investigated the influence of arterial P C O 2 ( P aC O 2 ) with and without acute experimental metabolic alkalosis on neurovascular coupling (NVC). We assessed stepwise iso-oxic alterations in P aC O 2 prior to and following intravenous NaHCO3 to acutely elevate arterial pH and [HCO3 - ]. The NVC response was not altered following NaHCO3 between stepwise P aC O 2 stages; therefore, NVC is acutely mediated by P aC O 2 rather than the prevailing arterial [H+ ]/pH. The NVC response was attenuated by 27-38% with -10 mmHg P aC O 2 and the absolute peak change was reduced by -19% with +10 mmHg P aC O 2 irrespective of acutely elevated arterial pH/[HCO3 - ]. The NVC kinetics (i.e. time to peak) were markedly slower with hypercapnia versus hypocapnia (24 ± 5 vs. 7 ± 5 s, respectively) likely indicating an influence of resting cerebrovascular tone on NVC responsiveness. Elevations in cerebral metabolism necessitate appropriate coordinated and localized increases in cerebral blood flow (i.e. neurovascular coupling; NVC). Recent pre-clinical work indicates that arterial P C O 2 ( P aC O 2 ) mediates NVC independently of arterial/extracellular pH; this has yet to be experimentally tested in humans. The goal o...Continue Reading

References

Apr 11, 1978·The American Journal of Physiology·H A KontosJ L Patterson
Apr 1, 1976·Respiration Physiology·S J England, L E Farhi
Oct 1, 1992·Stroke; a Journal of Cerebral Circulation·K FujiiF M Faraci
Sep 1, 1991·Circulation Research·K FujiiF M Faraci
Jan 1, 1990·Circulation Research·F M Faraci, D D Heistad
Jul 1, 1988·The American Journal of Physiology·F M FaraciD D Heistad
Jul 1, 1971·The American Journal of Physiology·H M ShapiroC A Wiederhielm
Dec 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation·N A Lassen
Jul 1, 1980·Stroke; a Journal of Cerebral Circulation·V A MaximilianJ Risberg
Apr 1, 1981·Pflügers Archiv : European journal of physiology·N TakanoY Iida
Dec 1, 1982·Pflügers Archiv : European journal of physiology·H R Ahmad, H H Loeschcke
Oct 1, 1995·Circulation Research·A C Ngai, H R Winn
May 1, 1995·Stroke; a Journal of Cerebral Circulation·W MengD W Busija
Apr 1, 1994·The Journal of General Physiology·U Klöckner, G Isenberg
Oct 1, 1996·The American Journal of Physiology·C Iadecola, F Zhang
Dec 1, 1996·The American Journal of Physiology·R S SpragueA J Lonigro
Jan 1, 1997·The American Journal of Physiology·H OkamotoJ P Kampine
Apr 1, 1997·The American Journal of Physiology·G Yang, C Iadecola
Dec 31, 1997·Stroke; a Journal of Cerebral Circulation·N Thorin-TrescasesJ A Bevan
Jul 18, 2001·Journal of Applied Physiology·R J WoodmanD Green
Jan 25, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Albert GjeddeManouchehr Vafaee
Feb 8, 2003·European Journal of Ultrasound : Official Journal of the European Federation of Societies for Ultrasound in Medicine and Biology·Bernhard RosengartenManfred Kaps
May 1, 1961·Journal of Applied Physiology·C J LAMBERTSENR GELFAND
Jun 4, 2004·Journal of Cardiovascular Pharmacology·Marilyn J CipollaLisa Vitullo
Oct 14, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Tamara M ParaviciniChristopher G Sobey
Dec 21, 2005·Neuron·Chris G DullaSusan A Masino
Jul 31, 2007·Glia·Angus M Brown, Bruce R Ransom
Jul 12, 2008·Journal of Applied Physiology·Karen C PeeblesPhilip N Ainslie
Feb 13, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Philip N Ainslie, James Duffin
Nov 27, 2009·Journal of Neurophysiology·Sachin Makani, Mitchell Chesler
Nov 12, 2010·Nature·David AttwellEric A Newman
Aug 13, 2011·Journal of the Neurological Sciences·Katalin SzaboLaszlo Olah

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.