PMID: 15362480Sep 15, 2004Paper

Alterations in atrial natriuretic peptide and its receptors in streptozotocin-induced diabetic rat kidneys

Molecular and Cellular Biochemistry
E N ObinecheA Adem

Abstract

In this study the effect of diabetes mellitus on atrial natriuretic peptide (ANP) receptors in streptozotocin- (STZ-) induced diabetic rat kidneys was studied. Moreover, plasma ANP concentration was evaluated in diabetic and control rats by using radioimmunoassay. In addition, the expression of ANP in the kidneys of control and diabetic rats was evaluated by immunohistochemistry. Body-weight loss and increased glucose levels were used as indices of diabetes mellitus in the STZ-induced rats. There was a significant loss in the body weight of the diabetic rats compared to controls. The efficacy of STZ administration was confirmed by rising blood glucose levels, which were significantly higher in diabetic rats compared to controls. Plasma ANP concentration was significantly greater in the diabetic rats in comparison with controls. Moreover, our immunohistochemical results show that the expression of ANP in diabetic rats was higher than that in age-matched controls. ANP was observed in the cells lining the proximal convoluted tubules in the cortex. The distribution and levels of ANP receptors in the kidneys of diabetic rats and age-matched controls were investigated using quantitative receptor autoradiography. Our results demonstra...Continue Reading

Citations

Dec 8, 2006·Annals of the New York Academy of Sciences·Enyioma ObinecheAbdu Adem
Mar 20, 2010·Molecular and Cellular Biochemistry·Salim M A BastakiAbdu Adem
Aug 18, 2010·Doklady. Biochemistry and Biophysics·A O ShpakovM N Pertseva

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