PMID: 8962438Oct 1, 1996Paper

Alterations in brain distribution of methamphetamine in methamphetamine-sensitized animals

Nihon Shinkei Seishin Yakurigaku Zasshi = Japanese Journal of Psychopharmacology
M Mizugaki

Abstract

[11C]Methamphetamine ([11C]MAP) was synthesized by an automated on-line [11C]methylation system for a position emission tomography (PET) study. The author newly prepared a MAP-sensitized dog by repeated treatment of MAP, and studied the brain distribution of [11C]MAP in normal and MAP.sensitized dogs. The maximal level of accumulation of [11C]MAP in the sensitized dog brain was 1.4 times higher than that in the control. No difference was found in the metabolism of MAP between the two conditions. A significant increase in [11C]MAP uptake into the sensitized dog brain was prevented by haloperidol and cocaine pretreatments. These results suggest that changes in the pharmacokinetic profile of MAP in the brain affect the development or expression of MAP-induced behavioral sensitization.

References

Sep 1, 1992·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·R IwataT Ido
Apr 1, 1991·Journal of Neurochemistry·H T PanJ B Justice
Mar 1, 1974·Pharmacology, Biochemistry, and Behavior·D S Segal, A J Mandell

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Citations

Jun 26, 2014·BMC Veterinary Research·Zengyang Pei, Xu Zhang

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