Alterations in calcium stores in aortic myocytes from spontaneously hypertensive rats

Hypertension
S F CôrtesJ C Stoclet

Abstract

The aim of the present work was to further characterize intracellular calcium stores released by angiotensin II (Ang II) in spontaneously hypertensive rat (SHR) and Wistar-Kyoto rat (WKY) vascular smooth muscle cells (VSMCs) and to study their alterations associated with proliferation. Intracellular Ca2+ concentration was monitored by image analysis in aortic myocytes loaded with fura 2. In the presence of extracellular Ca2+, sensitivity to Ang II in proliferating VSMCs was not different in the two strains, but it increased 10-fold in confluent VSMCs from SHR-compared with those from WKY. In Ca(2)+-free medium, Ca2+ release induced by thapsigargin (10 mumol/L) was significantly greater (about twofold) in SHR than WKY, in both proliferating and confluent cultures, with responses during proliferation being 0.7-fold smaller. Responses to Ang II were abolished after exposure of the cells to thapsigargin. In proliferating cultures, ryanodine (10 mumol/L) did not modify the rises in intracellular Ca2+ concentration induced by Ang II in VSMCs from both strains. Conversely, in confluent cultures, ryanodine reduced Ang II (100 nmol/L)-induced Ca2+ release to the same level as in proliferating cultures, and it suppressed the difference b...Continue Reading

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Citations

Mar 19, 1999·Clinical and Experimental Pharmacology & Physiology·C Baylis
Mar 19, 1999·Clinical and Experimental Pharmacology & Physiology·D M Pollock
Jul 16, 1999·Clinical and Experimental Pharmacology & Physiology·A M Lompré
Oct 9, 2002·Clinical and Experimental Pharmacology & Physiology·Emmanuel SamainJean-François Renaud
Mar 11, 2004·Clinical and Experimental Pharmacology & Physiology·Emmanuel SamainJean-François Renaud
Nov 1, 2002·Journal of Hypertension·Marie-Aude Devynck
May 25, 2002·Kidney International·Susan K Fellner, William J Arendshorst
Jul 18, 2012·European Journal of Pharmacology·Chaweewan JansakulYouwapa Sukpondma
Jul 29, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Cristina Porras-GonzálezJuan Ureña
Feb 24, 2012·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Eun Ji KimSe Hoon Kim
Jan 3, 2019·American Journal of Physiology. Cell Physiology·Helena W Morrison, Jessica A Filosa
Jan 21, 2010·Physiological Reviews·Susan Wray, Theodor Burdyga
Nov 6, 2007·American Journal of Physiology. Cell Physiology·Lih Chyuan NgJoseph R Hume
Jan 14, 1999·The American Journal of Physiology·G J LagaudR Andriantsitohaina
Jul 18, 2001·American Journal of Physiology. Renal Physiology·M Salomonsson, W J Arendshorst

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