PMID: 10067657Mar 6, 1999

Alterations in carbohydrate and lipid metabolism induced by a diet rich in coconut oil and cholesterol in a rat model

Journal of the American College of Nutrition
M A ZuletJ Alfredo Martínez


The type of dietary fat as well as the amount of cholesterol occurring in the diet have been associated with several metabolic disorders. Thus, the aim of the present study was to investigate the influence of a hypercholesterolemic diet enriched with coconut oil and cholesterol on carbohydrate and lipid metabolism in a rat model. Twenty male Wistar rats weighing about 190 g were assigned to two dietary groups. One group received a semipurified control diet and the other was given a diet enriched in coconut oil (25% by weight) and cholesterol (1% by weight) for 26 days. Our results indicated a significant increase in serum total cholesterol (+285%; p<0.001), low-density lipoproteins (+154%; p<0.01), liver cholesterol (+1509%; p<0.001), as well as a significant increase in liver weight (+46%; p<0.001) in those rats fed the hypercholesterolemia-inducing diet as compared to controls. Moreover, a significant decrease in serum high-density lipoproteins (-67%; p<0.001), triacylglycerols levels (-33%; p<0.05), and abdominal fat weight (-39%; p<0.01) were found. The observed alterations in serum lipid and lipoprotein profile resembled a situation of type IIa hyperlipidemia in humans. Measurement of several enzymes concerned with lipid u...Continue Reading


Feb 1, 1991·The Journal of Clinical Endocrinology and Metabolism·M BorkmanL H Storlien
Oct 15, 1991·Biochemical and Biophysical Research Communications·J OsadaE Palacios-Alaiz
Jan 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·R J NicolosiE J Schaefer
Jan 1, 1986·Methods in Enzymology·J J AlbersA G Lacko
Jan 1, 1987·Annual Review of Nutrition·J D McGarryJ Katz
Jan 1, 1981·Methods in Enzymology·D A KleinsekJ W Porter
Jul 1, 1995·Metabolism: Clinical and Experimental·M L FernandezD J McNamara
Mar 28, 1995·Biochemical and Biophysical Research Communications·Y KimM Suzuki
Mar 1, 1995·The International Journal of Biochemistry & Cell Biology·P YaqoobP C Calder
Feb 1, 1995·Metabolism: Clinical and Experimental·F Assimacopoulos-JeannetB Jeanrenaud
Feb 15, 1994·The American Journal of Cardiology·G F WattsB Lewis
Mar 1, 1994·The American Journal of Clinical Nutrition·A S Truswell
Jul 1, 1993·The Biochemical Journal·P B Iynedjian
Oct 1, 1995·Plant Foods for Human Nutrition·M A Zulet, J A Martínez
Jan 1, 1996·Progress in Lipid Research·P Khosla, K Sundram
May 1, 1997·The American Journal of Clinical Nutrition·P M Kris-Etherton, S Yu
Mar 13, 1998·The American Journal of Clinical Nutrition·J D McGarry
Jan 1, 1996·Nutrition Research Reviews·A M Salter, D A White


Jan 21, 2010·Plant Foods for Human Nutrition·Verónica PiñeiroGermán Chamorro-Cevallos
Dec 6, 2012·Chinese Journal of Integrative Medicine·Kaladevi Siddhi VinayagamSachdanandam Panchanatham
Mar 26, 2011·Journal of Physiology and Biochemistry·Tiago Gomes AraújoVera Lúcia de Menezes Lima
Jul 27, 2007·Journal of Medicinal Food·Bartholomew I C BraiP U Agomo
Jul 4, 2007·Lipids in Health and Disease·Ricardo Luís Fernandes GuerraAna R Dâmaso
Jun 5, 2014·Nutrition Research Reviews·Stéphane PanseratSergio Polakof
Aug 2, 2011·Stress : the International Journal on the Biology of Stress·V J NevesF K Marcondes
Oct 23, 2008·Metabolism: Clinical and Experimental·Eun-Mi JangMi-Kyung Lee
Oct 12, 2013·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·O O OnabanjoO O Obanla
Mar 8, 2014·International Journal of Experimental Pathology·Roxana OberkerschGraciela C Calabrese
May 3, 2016·Journal of Pharmacy & Bioallied Sciences·Neelam Mallick, Rafeeq Alam Khan
Jun 23, 2015·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Walid Hamdy El-TantawyKamilia F Taha
Feb 29, 2008·The American Journal of Chinese Medicine·Myung-Sook ChoiMi-Kyung Lee
Aug 30, 2008·The British Journal of Nutrition·Nerea Pérez-EcharriMaría J Moreno-Aliaga
Nov 25, 2017·Archives of Physiology and Biochemistry·Intissar KammounIbtissem Ben Amara
Nov 27, 2019·British Journal of Pharmacology·Ioanna AndreadouPéter Ferdinandy
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Related Concepts

Coconut Oil
Blood Glucose
Cholesterol, Dietary
Vegetable Oils
Rats, Wistar
Carbohydrate Metabolism

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