PMID: 10067657Mar 6, 1999

Alterations in carbohydrate and lipid metabolism induced by a diet rich in coconut oil and cholesterol in a rat model

Journal of the American College of Nutrition
M A ZuletJ Alfredo Martínez

Abstract

The type of dietary fat as well as the amount of cholesterol occurring in the diet have been associated with several metabolic disorders. Thus, the aim of the present study was to investigate the influence of a hypercholesterolemic diet enriched with coconut oil and cholesterol on carbohydrate and lipid metabolism in a rat model. Twenty male Wistar rats weighing about 190 g were assigned to two dietary groups. One group received a semipurified control diet and the other was given a diet enriched in coconut oil (25% by weight) and cholesterol (1% by weight) for 26 days. Our results indicated a significant increase in serum total cholesterol (+285%; p<0.001), low-density lipoproteins (+154%; p<0.01), liver cholesterol (+1509%; p<0.001), as well as a significant increase in liver weight (+46%; p<0.001) in those rats fed the hypercholesterolemia-inducing diet as compared to controls. Moreover, a significant decrease in serum high-density lipoproteins (-67%; p<0.001), triacylglycerols levels (-33%; p<0.05), and abdominal fat weight (-39%; p<0.01) were found. The observed alterations in serum lipid and lipoprotein profile resembled a situation of type IIa hyperlipidemia in humans. Measurement of several enzymes concerned with lipid u...Continue Reading

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Citations

Jan 21, 2010·Plant Foods for Human Nutrition·Verónica PiñeiroGermán Chamorro-Cevallos
Dec 6, 2012·Chinese Journal of Integrative Medicine·Kaladevi Siddhi VinayagamSachdanandam Panchanatham
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Related Concepts

Coconut Oil
Blood Glucose
Cholesterol, Dietary
Hypercholesterolemia
Novolin
LDL-1
Liver
Vegetable Oils
Rats, Wistar
Carbohydrate Metabolism

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