Alterations in cardiac structure and function in a murine model of chronic alcohol consumption

Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada
Brittany A LawWayne E Carver

Abstract

Male, wild-type, FVB strain mice were fed a nutritionally complete liquid diet supplemented with 4% ethanol v/v over a time course of 1, 2, 4, 8, 12, and 14 weeks. Controls were offered an isocaloric liquid equivalent and pair fed with their ethanol counterparts. Changes in cardiac physiology were assessed at respective time points via echocardiography. Additionally, the use of histological techniques, mRNA analysis, apoptosis determination, and immunohistochemistry were employed to determine the functional and structural changes on the heart. Echocardiograph analysis revealed a compensatory phase that occurred early in the time course (1-8 weeks) and decompensation reverting toward heart failure at weeks 12 and 14. Throughout the study, an increase in cardiomyocyte hypertrophy, cardiac fibrosis, apoptosis, TGF-β, and the presence of α-SMA-positive cells were determined. A compensatory period in mice treated with ethanol occurred early followed by a transition to a dilated phenotype over time. A number of factors may be involved in this process including the activation of myofibroblasts and their fibrotic activities that is correlated with the presence of transforming growth factor beta.

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Citations

May 8, 2013·Cellular and Molecular Life Sciences : CMLS·Ping KongNikolaos G Frangogiannis
Jan 22, 2013·Life Sciences·Vennece FowlkesEdie C Goldsmith
Mar 27, 2013·Alcoholism, Clinical and Experimental Research·Brittany A Law, Wayne E Carver
Sep 17, 2013·Alcoholism, Clinical and Experimental Research·Elia C El HajjJason D Gardner
Jun 26, 2015·Alcoholism, Clinical and Experimental Research·Jennifer L SteinerCharles H Lang
May 18, 2016·Journal of Molecular and Cellular Cardiology·Randy T Cowling
Sep 10, 2019·Alcoholism, Clinical and Experimental Research·Jie XiongQing Su
Oct 19, 2017·International Journal of Molecular Medicine·Biao LiangJun Yang
Nov 3, 2020·Cardiovascular Research·Nikolaos G Frangogiannis
Jan 6, 2021·Cells·William P LafuseMurugesan V S Rajaram
Jul 30, 2018·Molecular Aspects of Medicine·Nikolaos G Frangogiannis

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis