Abstract
Male, wild-type, FVB strain mice were fed a nutritionally complete liquid diet supplemented with 4% ethanol v/v over a time course of 1, 2, 4, 8, 12, and 14 weeks. Controls were offered an isocaloric liquid equivalent and pair fed with their ethanol counterparts. Changes in cardiac physiology were assessed at respective time points via echocardiography. Additionally, the use of histological techniques, mRNA analysis, apoptosis determination, and immunohistochemistry were employed to determine the functional and structural changes on the heart. Echocardiograph analysis revealed a compensatory phase that occurred early in the time course (1-8 weeks) and decompensation reverting toward heart failure at weeks 12 and 14. Throughout the study, an increase in cardiomyocyte hypertrophy, cardiac fibrosis, apoptosis, TGF-β, and the presence of α-SMA-positive cells were determined. A compensatory period in mice treated with ethanol occurred early followed by a transition to a dilated phenotype over time. A number of factors may be involved in this process including the activation of myofibroblasts and their fibrotic activities that is correlated with the presence of transforming growth factor beta.
References
Nov 21, 1975·Science·E BaraonaC S Lieber
Sep 1, 1989·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·N B SchillerI Schnittger
Jan 1, 1988·Cardiology·K SilberbauerC Hess
May 1, 1986·Alcohol·D R Pierce, J R West
Jan 1, 1982·Alcoholism, Clinical and Experimental Research·C S Lieber, L M DeCarli
Mar 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P BedossaT Poynard
Oct 1, 1993·Alcoholism, Clinical and Experimental Research·V T SavolainenP J Karhunen
Jun 1, 1997·Die Naturwissenschaften·J RameckersB Herrmann
Jun 3, 1999·Circulation·M PauschingerH P Schultheiss
Oct 14, 2000·Cell Research·J H Zhang, M Xu
Jan 30, 2003·Journal of Cardiac Failure·Blase A Carabello
Jan 30, 2003·Journal of Cardiac Failure·A Martin Gerdes
Mar 27, 2003·Alcohol·Shann D KimMariann R Piano
Jan 25, 2005·Nature Medicine·Eiki TakimotoDavid A Kass
Jul 27, 2006·Human Pathology·Joaquim Fernández-SolàJosé-María Nicolás
Apr 18, 2008·Current Atherosclerosis Reports·Luc Djoussé, J Michael Gaziano
May 28, 2008·Biochemical and Biophysical Research Communications·Jun YuJoseph J Y Sung
Jun 19, 2008·Biochemical and Biophysical Research Communications·Kun-Lin YangChia-Chang Chuang
Apr 1, 2009·Circulation·Thomas A DoserJun Ren
Apr 2, 2009·European Journal of Heart Failure·Irma LaonigroEmanuele Altomare
Apr 4, 2009·Physiological Reviews·Rainer Spanagel
Apr 7, 2009·Journal of Molecular and Cellular Cardiology·Shi-Yan LiJun Ren
Jul 16, 2009·Journal of Leukocyte Biology·Darren M BoéMarc Moss
Aug 22, 2009·Journal of Molecular and Cellular Cardiology·Corrine R KlimentTim D Oury
Aug 4, 2010·Free Radical Biology & Medicine·Bingfang ZhangJun Ren
Nov 10, 2010·Journal of Molecular and Cellular Cardiology·Marcin DobaczewskiNikolaos G Frangogiannis
Apr 2, 2011·The Journal of Biological Chemistry·Ariane Melchior-BeckerJens W Fischer
Jul 28, 2011·Journal of Cellular Physiology·Jacqueline HegerGerhild Euler
Citations
May 8, 2013·Cellular and Molecular Life Sciences : CMLS·Ping KongNikolaos G Frangogiannis
Jan 22, 2013·Life Sciences·Vennece FowlkesEdie C Goldsmith
Mar 27, 2013·Alcoholism, Clinical and Experimental Research·Brittany A Law, Wayne E Carver
Sep 17, 2013·Alcoholism, Clinical and Experimental Research·Elia C El HajjJason D Gardner
Jun 26, 2015·Alcoholism, Clinical and Experimental Research·Jennifer L SteinerCharles H Lang
Jun 25, 2015·Journal of Cardiac Failure·Andrew R RaymondRichard L Brooksbank
Jan 20, 2015·Toxicology·Susana M SilvaSandra Leal
May 18, 2016·Journal of Molecular and Cellular Cardiology·Randy T Cowling
Jul 27, 2018·Alcoholism, Clinical and Experimental Research·Chi ZhouDao Wen Wang
Sep 10, 2019·Alcoholism, Clinical and Experimental Research·Jie XiongQing Su
Oct 19, 2017·International Journal of Molecular Medicine·Biao LiangJun Yang
May 3, 2019·Oxidative Medicine and Cellular Longevity·Xinran CaoBo Dong
Nov 3, 2020·Cardiovascular Research·Nikolaos G Frangogiannis
Jan 6, 2021·Cells·William P LafuseMurugesan V S Rajaram
Jul 30, 2018·Molecular Aspects of Medicine·Nikolaos G Frangogiannis