PMID: 9540850Apr 16, 1998Paper

Alterations in carnitine-acylcarnitine translocase activity and in phospholipid composition in heart mitochondria from hypothyroid rats

Biochimica Et Biophysica Acta
G ParadiesE Quagliariello

Abstract

Changes in mitochondrial fatty acid metabolism may underlie the decline in cardiac function in the hypothyroid animals. The effect of hypothyroidism on fatty acid oxidation, carnitine-acylcarnitine translocase activity and lipid composition in rat heart mitochondria has been examined. Rates of mitochondrial fatty acid oxidation as well as carnitine-carnitine and carnitine-palmitoylcarnitine exchange reactions were all depressed in heart mitochondria isolated from hypothyroid rats. Kinetic analysis of the carnitine-carnitine exchange reaction showed that the hypothyroid state affects the Vmax of this process, while having no effect on the K(m) value. Heart mitochondrial inner membrane lipid composition was significantly altered in hypothyroid rats. Cardiolipin, particularly, was found to decrease (by around 36%). Alterations in fatty acid pattern of mitochondrial inner membrane preparations from hypothyroid rats were also found. The effects of the hypothyroid state on fatty acids oxidation, carnitine translocase activity and phospholipid composition were completely reversed by following treatment of hypothyroid rats with thyroid hormone. A lower cardiolipin content in the mitochondrial inner membrane offers a plausible mechanism...Continue Reading

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Citations

May 11, 2004·Pflügers Archiv : European journal of physiology·Monika GóreckaEwa Zernicka
Oct 8, 2013·Antioxidants & Redox Signaling·Giuseppe ParadiesGiuseppe Petrosillo
Jul 16, 2011·Journal of Thyroid Research·Martha FrancoOscar Pérez-Méndez
Jul 20, 2010·Chemico-biological Interactions·Izabela DobrzyńskaZbigniew Figaszewski
Jun 23, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M M Sayed-AhmedM Calvani
Oct 25, 2011·Molecular Aspects of Medicine·Cesare IndiveriFerdinando Palmieri
Mar 12, 2009·Journal of Cardiovascular Pharmacology·Genevieve C Sparagna, Edward J Lesnefsky
May 8, 2013·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yasuhito Nakagawa
Aug 11, 2006·American Journal of Physiology. Cell Physiology·Adam J Chicco, Genevieve C Sparagna
Jul 2, 2009·American Journal of Veterinary Research·John H RossmeislG Diane Shelton
Aug 18, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Giuseppe PetrosilloGiuseppe Paradies
Nov 14, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mauro SerricchioPeter Bütikofer
Jan 30, 2002·Progress in Lipid Research·Simon Eaton
May 9, 2000·Progress in Lipid Research·M SchlameM L Greenberg

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