Alterations in CD200-CD200R1 System during EAE Already Manifest at Presymptomatic Stages

Frontiers in Cellular Neuroscience
Tony ValenteCarme Solà

Abstract

In the brain of patients with multiple sclerosis, activated microglia/macrophages appear in active lesions and in normal appearing white matter. However, whether they play a beneficial or a detrimental role in the development of the pathology remains a controversial issue. The production of pro-inflammatory molecules by chronically activated microglial cells is suggested to contribute to the progression of neurodegenerative processes in neurological disease. In the healthy brain, neurons control glial activation through several inhibitory mechanisms, such as the CD200-CD200R1 interaction. Therefore, we studied whether alterations in the CD200-CD200R1 system might underlie the neuroinflammation in an experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis. We determined the time course of CD200 and CD200R1 expression in the brain and spinal cord of an EAE mouse model from presymptomatic to late symptomatic stages. We also assessed the correlation with associated glial activation, inflammatory response and EAE severity. Alterations in CD200 and CD200R1 expression were mainly observed in spinal cord regions in the EAE model, mostly a decrease in CD200 and an increase in CD200R1 expression. A decrease in the exp...Continue Reading

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Citations

Mar 18, 2020·International Journal of Rheumatic Diseases·Ting-Ting LiuAn-Mei Deng
Oct 28, 2019·Frontiers in Immunology·Silvina Romero-SuárezCarmen Infante-Duarte
Aug 24, 2019·Frontiers in Neuroscience·Xu ZhaoHaitao Sun
Oct 18, 2020·Brain and Behavior·Shou-Cai ZhaoYang Xu
Apr 8, 2021·Journal of Neuroinflammation·Neus Rabaneda-LombarteCarme Solà
Oct 1, 2019·Journal of Autoimmunity·Chuan HuangZhe-Xiong Lian

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Methods Mentioned

BETA
GTPase

Software Mentioned

GraphPad Prism
GraphPad
CFX

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