Alterations in cell cycle and induction of apoptotic cell death in breast cancer cells treated with α-mangostin extracted from mangosteen pericarp.

Journal of Biomedicine & Biotechnology
Hitomi KuroseYoshinori Otsuki

Abstract

The development of molecularly targeted drugs has greatly advanced cancer therapy, despite these drugs being associated with some serious problems. Recently, increasing attention has been paid to the anticancer effects of natural products. α-Mangostin, a xanthone isolated from the pericarp of mangosteen fruit, has been shown to induce apoptosis in various cancer cell lines and to exhibit antitumor activity in a mouse mammary cancer model. In this study, we investigated the influence of α-mangostin on apoptosis and cell cycle in the human breast cancer cell line MDA-MB231 (carrying a p53 mutation, and HER2, ER, and PgR negative) in order to elucidate its anticancer mechanisms. In α-mangostin-treated cells, induction of mitochondria-mediated apoptosis was observed. On cell-cycle analysis, G1-phase arrest, increased p21(cip1) expression and decreases in cyclins, cdc(s), CDKs and PCNA were observed. In conclusion, α-mangostin may be useful as a therapeutic agent for breast cancer carrying a p53 mutation and having HER2- and hormone receptor-negative subtypes.

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Citations

Aug 6, 2013·Apoptosis : an International Journal on Programmed Cell Death·Shu-Ching HsiehYi-Hsien Hsieh
Jan 16, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·João BarbosaMadalena Pedro
Apr 5, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Ronaldo Carvalho-SilvaFabrício Rios-Santos
Apr 16, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Muhammad TaherZainul Amiruddin Zakaria
Feb 1, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yeong-Seon WonKwon-Il Seo
Jul 3, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yoshiyuki MizushinaHiromi Yoshida
Aug 2, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Hyun-Ho KwakSu-Bin Yu
Jul 5, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hui-Fang Chang, Ling-Ling Yang
May 21, 2015·European Journal of Drug Metabolism and Pharmacokinetics·Yan ZhaoShijie Wang
Mar 20, 2014·The Journal of Pharmacy and Pharmacology·Primchanien MoongkarndiNarongchai Pongpan
Jan 6, 2017·Oxidative Medicine and Cellular Longevity·Jazmin M Pérez-RojasPatricia García-López

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Methods Mentioned

BETA
Assay
Protease Assay
ELISA
Flow Cytometric
PCR
flow cytometry

Software Mentioned

Multicycle Cell - Cycle Analysis

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