Abstract
Progressive cell injury occurs with shock and ischemia, beginning with functional changes in the cell and cell membrane. Membrane transport and potential decrease, Na+ enters and K+ leaves cells; N+-K+ adenosine triphosphatase is activated, adenosine triphosphate (ATP) is used, and mitochondria are stimulated as increased lactate produces acidosis. Energy and cyclic adenosine monophosphate levels decrease, Ca2+ regulation is compromised, and nuclear function and protein synthesis are depressed. The cell swells, and further membrane changes occur with altered hormonal effects and mitochondrial uncoupling. Finally, lysosomes leak, intracellular and mitochondria disruption occurs, and the cell is destroyed. Based on these changes, attempts were made to directly support cell function during low-flow states. After volume replacement and vasoactive agents, other modalities, eg, substrates, membrane-stabilizing solutions, osmotic agents, and energy compounds were used. The use of ATP-MgCl2 was helpful in many experimental low-flow states, with an improvement in cell function mediated by micro-circulatory, cell membrane, or energy-recycling effects. Clinical examples of altered cell and organ function with ischemia and shock are numero...Continue Reading
Citations
Jan 11, 2012·Environmental Health and Toxicology·Hyonok YoonHan-Jung Chae
Jun 1, 1991·Annals of Surgery·J A EvansD S Gann
Dec 1, 1989·Transplantation·Y UedaT E Starzl
Nov 8, 2001·European Journal of Pharmacology·M LaM Perretti
Jul 1, 1986·The Proceedings of the Nutrition Society·M J McMahon
Oct 1, 1986·British Journal of Plastic Surgery·M F AngelJ W Futrell
Oct 18, 2002·Neuroscience Letters·Megan Paskitti, Kenneth H Reid
Oct 30, 2007·Acta Orthopaedica·Colin G MurphyDavid J Bouchier-Hayes
Jan 1, 1983·Clinical and Experimental Dialysis and Apheresis·H HirasawaH Sato
Sep 1, 1991·Transplant International : Official Journal of the European Society for Organ Transplantation·R M Wijnen, C J van der Linden
Apr 20, 2010·Injury·Bensu KarahalilSelçuk Bölükbaşi
Sep 1, 1987·Medical Hypotheses·R G CarrollE J Allison
Apr 1, 1993·Resuscitation·R W HickeyN G Bircher
May 1, 1985·The Journal of Surgical Research·B E SumpioA E Baue
Sep 1, 1984·The Journal of Surgical Research·M OhkawaA E Baue
Nov 1, 1986·The Journal of Surgical Research·W M Frederiks, G M Fronik
Jan 1, 1984·Acta Physiologica Scandinavica·J FornanderR Jagenburg
Nov 1, 1989·British Journal of Plastic Surgery·K R KnightB M O'Brien
Dec 1, 1990·American Journal of Surgery·F A MooreC M Abernathy
Jan 1, 1993·American Journal of Surgery·H J SteinH Lamprechts
Dec 25, 2009·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Tareq KheirbekHasan B Alam
Aug 10, 2010·The Journal of Surgical Research·Khoi Le MinhBrigitte Vollmar
Mar 23, 2017·The Journal of Trauma and Acute Care Surgery·Nathan J WhiteAndrew P Cap
Jan 1, 1984·The American Journal of Emergency Medicine·H Haljamäe
Jun 7, 2005·Biochimica Et Biophysica Acta·Heather L MontieDonald J Degracia
Oct 15, 1992·Experientia·M JellinekA E Baue
Jul 1, 1992·The Journal of Surgical Research·M F AngelB M O'Brien
Nov 1, 1990·Angiology·J E NaschitzJ Shahar
Aug 1, 1995·The Journal of Trauma·B D BorcheltD S Gann
Jan 1, 1989·Microsurgery·R K KhazanchiB M O'Brien
May 1, 1994·The British Journal of Surgery·P A Grace
Jan 1, 1994·Microsurgery·K R Knight
Jun 1, 1988·The British Journal of Surgery·R PrêtreA Rohner
Feb 1, 1996·The British Journal of Surgery·S C WeightM L Nicholson
Oct 1, 2009·Physiological Reviews·Brigitte Vollmar, Michael D Menger
Feb 1, 1989·Liver·Y UedaK Konomi
May 1, 1988·Basic Research in Cardiology·B TörökK Trombitás
Mar 1, 1983·The Japanese Journal of Surgery·A E Baue, D Guthrie
Sep 29, 2001·The Journal of the American Academy of Orthopaedic Surgeons·A WakaiP H Redmond
Jul 17, 1999·The American Journal of Physiology·R W BrockR F Potter
Jul 1, 1990·The Journal of Surgical Research·T R WalshT E Starzl