Alterations in cerebral energy metabolism induced by traumatic brain injury

Neurological Research
Y XiongC P Lee

Abstract

Energy metabolism of the brain is unique, possessing high aerobic metabolism with no significant capacity for anaerobic glycolysis and limited tissue stores of glucose. A steady supply of oxygen and glucose is essential in order to maintain cerebral function and integrity. Extensive research in experimental and human head injury has been conducted regarding the delivery of oxygen and outcome. This research has provided evidence which indicates that in addition to the availability of oxygen and glucose, other factors, such as perturbation of mitochondrial energy transducing processes which also follow head trauma, play significant roles. In this paper, the salient findings from biochemical studies of experimental and clinical brain injury are summarized and indicate that the mitochondrial respiratory chain-linked oxidative phosphorylation and calcium transport are compromised by trauma-induced brain injury and support the idea that oxidative stress and perturbation of cellular calcium homeostasis play significant roles in traumatic brain injury.

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Citations

Dec 28, 2012·Journal of Neurotrauma·Tyler A KokjohnAlex E Roher
Nov 26, 2013·Brain Injury : [BI]·Helen W PhippsJacob W Vanlandingham
Sep 10, 2015·Reviews in the Neurosciences·Rajaneesh Gupta, Nilkantha Sen
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May 29, 2018·Experimental and Therapeutic Medicine·Jianping SunJianliang Wu
May 1, 2018·The Journal of International Medical Research·Nissim OhanaAbraham Cohen
May 6, 2021·Biomedicines·Hilary Y LiuElias Aizenman

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