Alterations in cerebral white matter and neuropsychology in patients with cirrhosis and falls

PloS One
Beatriz Gómez-AnsónGermán Soriano

Abstract

Falls are frequent in patients with cirrhosis but underlying mechanisms are unknown. The aim was to determine the neuropsychological, neurological and brain alterations using magnetic resonance-diffusion tensor imaging (MR-DTI) in cirrhotic patients with falls. Twelve patients with cirrhosis and falls in the previous year were compared to 9 cirrhotic patients without falls. A comprehensive neuropsychological and neurological evaluation of variables that may predispose to falls included: the Mini-Mental State Examination, Psychometric Hepatic Encephalopathy Score (PHES), Parkinson's Disease-Cognitive Rating Scale, specific tests to explore various cognitive domains, Unified Parkinson's Disease Rating Scale to evaluate parkinsonism, scales for ataxia and muscular strength, and electroneurography. High-field MR (3T) including DTI and structural sequences was performed in all patients. The main neuropsychological findings were impairment in PHES (p = 0.03), Parkinson's Disease-Cognitive Rating Scale (p = 0.04) and in executive (p<0.05) and visuospatial-visuoconstructive functions (p<0.05) in patients with falls compared to those without. There were no statistical differences between the two groups in the neurological evaluation or ...Continue Reading

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Citations

Jan 28, 2018·Metabolic Brain Disease·Xiao Dong Zhang, Long Jiang Zhang
Oct 18, 2018·Digestive Diseases and Sciences·Susan L MurphyJames K Richardson
Oct 9, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Eva RománGerman Soriano

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Methods Mentioned

BETA
biopsy

Software Mentioned

Freesurfer
GranMo
FMRIB Software Library (
SPSS
DTIFIT
FMRIB Diffusion Toolbox

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