PMID: 8597650Nov 1, 1995Paper

Alterations in circulating ovarian steroids in hexachlorobenzene-exposed monkeys

Reproductive Toxicology
W FosterP R Lecavalier

Abstract

Hexachlorobenzene (HCB) is a global pollutant that has been identified in human serum and ovarian follicular fluid, and its effect on ovarian function has not been adequately defined. Thus, the effects of HCB on ovarian steroidogenesis and menstrual cycle characteristics were investigated in cynomolgus monkeys (n = 16) orally dosed by gelatin capsule (0.0, 0.1, 1.0, and 10.0 mg HCB/kg b.wt./d) for 90 d (approximately three menstrual cycles). Analysis of change in menstrual cycle length for each animal revealed a dose-dependent increase (P = 0.02) in cycle length. Ovulatory levels of estradiol (E2) were significantly reduced (P = 0.02) in the highest treatment group. During ovulation induction, the area under the E2 concentration curve (AUC) was significantly (P = 0.03) suppressed in the highest treatment group. Our data demonstrate that HCB treatment, under the conditions of the present study, alters both ovarian function and menstrual cycle characteristics with a no observable adverse effect level of 1.0 mg/kg.

References

Sep 1, 1978·Ecotoxicology and Environmental Safety·W F MüllerF Korte
Sep 1, 1976·Toxicology and Applied Pharmacology·M J IatropoulosH P Adams
Jan 1, 1975·Archives of Environmental Health·J E Burns, F M Miller
Jan 1, 1985·Annals of the New York Academy of Sciences·V BauklohP Kemeter
May 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E S Feldman, B R Bacon
Feb 1, 1986·Bulletin of Environmental Contamination and Toxicology·G A AnsariE S Reynolds
Jan 1, 1988·Journal of Biochemical Toxicology·M RizzardiniL Cantoni
Jan 16, 1985·Biochemical and Biophysical Research Communications·B van OmmenF Müller
May 1, 1981·The Journal of Clinical Endocrinology and Metabolism·S G HillierE V Van Hall
Mar 1, 1980·Journal of Toxicology and Environmental Health·M F CurrierG Barna-Lloyd
Mar 1, 1994·Bulletin of Environmental Contamination and Toxicology·J K Ludwicki, K Góralczyk
Mar 1, 1994·The Journal of Endocrinology·C D SmythS G Hillier
Dec 1, 1993·Bulletin of Environmental Contamination and Toxicology·C CondeC Arrabal
Jan 1, 1993·Reproductive Toxicology·J F JarrellS Bartlett

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Citations

Dec 17, 2009·Journal of Exposure Science & Environmental Epidemiology·Willem DhoogeNicolas van Larebeke
Mar 4, 2010·Journal of Exposure Science & Environmental Epidemiology·Elly Den HondNicolas van Larebeke
Jun 2, 2006·Reproductive Biology and Endocrinology : RB&E·Reini W BretveldNel Roeleveld
Aug 6, 2009·Environmental Health Perspectives·Maria Grazia PorporaElena De Felip
May 26, 2004·Environmental Health Perspectives·Janine EzendamJoseph G Vos
Jan 9, 2015·Environment International·Jayshree Annamalai, Vasudevan Namasivayam
Jun 24, 2009·International Journal of Hygiene and Environmental Health·K CroesN Van Larebeke
Aug 21, 2014·Environmental Science and Pollution Research International·K CroesW Baeyens
Jul 31, 2010·Journal of Environmental and Public Health·Rosana H WeldonBrenda Eskenazi
Dec 31, 2014·International Journal of Hygiene and Environmental Health·Nik Van LarebekeWilly Baeyens
Dec 1, 1995·Environmental Health Perspectives·W G Foster
Oct 30, 2008·Journal of Immunotoxicology·Janine EzendamRaymond Pieters
Mar 25, 2018·Endocrine Connections·Bilal B MughalBarbara A Demeneix
Oct 28, 2009·The Behavioral and Brain Sciences·Nicholas Evans, Stephen C Levinson
Dec 17, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Andrea E Martin, Leonidas A A Doumas
Nov 13, 2017·Pharmacological Reports : PR·Beata Starek-ŚwiechowiczAndrzej Starek
May 1, 1996·Toxicology and Industrial Health·W G FosterS Jordan

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