PMID: 6627045Aug 1, 1983Paper

Alterations in CNS amine levels by acclimatization to hypobaric hypoxia

Brain Research Bulletin
M J HughesT Redington


Rabbits were acclimatized to simulated high altitude (SHA) (hypobaric hypoxia) at 6000 M (350 torr) on alternate days for 70 days. The norepinephrine levels of the midbrain were lower in the acclimatized animal compared to the controls (p less than 0.06) and 3,4 dihydroxyphenylacetic acid (DOPAC) was significantly higher (p less than 0.04) in the striatum of control than in the test animals. The mean dopamine (DA) levels in the striatum of the test animals were higher than the controls. The ratio of DOPAC/DA was 2.0 for the controls and 0.4 for the SHA brains which suggests reduced dopamine turnover in the striatum of the SHA rabbits. Rats acclimatized in the same manner did not show any difference in the NE or DA levels between the control and SHA animals, possibly the result of species differences.


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