Alterations in copper homeostasis and oxidative stress biomarkers in women using the intrauterine device TCu380A

Toxicology Letters
Nathalie ArnalCarlos A Marra

Abstract

Copper ions participate in the Häber-Weiss reaction to produce ROS, which can be toxic when in excess. The purpose of this study was to measure the copper concentration (Cu) in the plasma of women using Cu-IUDs and determine (i) the effect of Cu on oxidative stress biomarkers, (ii) the levels of copper transport proteins in the plasma and (iii) the status of some liver damage markers in relation to the length of the intrauterine device use. Thirty-nine controls and 35 T380-IUD users were recruited. Various oxidative stress biomarkers, ceruloplasmin (CRP), metallothioneins (MTs), Cu and enzyme activities involved in liver function were measured in the plasma. The Cu concentration was higher in women with IUDs, concomitantly with time-dependent increases in the main oxidative stress biomarkers (TBARS, protein carbonyls, glutathione and nitrates+nitrites), hepatic enzymes (LDH and transaminases), MTs and CRP. We concluded that the use of Cu-IUDs for more than 2 consecutive years should be avoided in order to prevent oxidative damage.

References

Apr 1, 1976·Biochemical Medicine·K Yagi
Jan 1, 1992·Free Radical Research Communications·C E CrossB Halliwell
Jan 1, 1988·Pharmacology & Therapeutics·M B AstorA Meister
Mar 15, 1986·Toxicology and Applied Pharmacology·A M Scheuhammer, M G Cherian
Jul 1, 1974·Fertility and Sterility·F HefnawiM Mousa
Mar 14, 1995·Biochimica Et Biophysica Acta·T ThomasP Rogers
Jan 1, 1994·Methods in Enzymology·A Z Reznick, L Packer
May 1, 1994·Toxicology and Applied Pharmacology·S Toyokuni, J L Sagripanti
Aug 1, 1993·Contraception·S AmlaN K Ganguly
Jan 1, 1996·Reproduction, Fertility, and Development·L RobleroF Zegers-Hochschild
May 9, 1997·The Science of the Total Environment·C Terrés-MartosM C López-Martínez
May 1, 1997·Contraception·M PradhanN K Ganguli
Aug 29, 1997·Chemistry and Physics of Lipids·B KartenA Kontush
Aug 17, 1999·Neurobiology of Disease·D J WaggonerJ D Gitlin
Mar 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·P C WongJ D Gitlin
Aug 30, 2000·Human & Experimental Toxicology·N S AstonG S Evans
Feb 17, 2001·Nitric Oxide : Biology and Chemistry·K M MirandaD A Wink
Apr 3, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·P M Abuja, R Albertini
Apr 11, 2001·Mutation Research·M C Linder
Jul 27, 2001·Brain Research Bulletin·D StrausakG Multhaup
Aug 11, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·A PrakasamS Lalitha
May 23, 2002·Cellular and Molecular Life Sciences : CMLS·P CoyleA M Rofe
Feb 19, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Isabella Dalle-DonneRoberto Colombo
Apr 12, 2003·Trends in Neurosciences·Ashley I Bush
Apr 23, 2003·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M BerkovitchJ Weissgarten
May 3, 2003·Trends in Molecular Medicine·Isabella Dalle-DonneAldo Milzani
Jun 25, 2003·Toxicology·Lisa M Gaetke, Ching Kuang Chow
Aug 14, 2003·Ecotoxicology and Environmental Safety·Jaqueline CalderónFernando Díaz-Barriga
Dec 4, 2003·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·H TapieroK D Tew
Dec 4, 2003·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Haim Tapiero, Kenneth D Tew
Mar 20, 2004·Nature Reviews. Drug Discovery·Kevin J BarnhamAshley I Bush
Apr 21, 2004·Journal of Alzheimer's Disease : JAD·Maurizio FacherisCarlo Ferrarese
Nov 13, 2004·Veterinary Research·Jose Joaquin Cerón, Silvia Martínez-Subiela
Dec 8, 2004·Critical Reviews in Neurobiology·Lucio TremolizzoCarlo Ferrarese
May 11, 2005·Toxicology and Applied Pharmacology·Gerhard KrumschnabelBettina Hofer
Jul 19, 2005·Contraception·Dolores De la CruzHoracio Tovalin

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Citations

Nov 26, 2015·Reproductive Toxicology·Tomasz KleszczewskiAnna Kostrzewska
Jun 28, 2011·Ecotoxicology and Environmental Safety·Nathalie ArnalCarlos A Marra
Apr 20, 2011·Chemico-biological Interactions·Nathalie ArnalCarlos A Marra
Dec 3, 2014·Environmental Toxicology and Pharmacology·Xuesheng ZhangZunyao Wang
Nov 30, 2013·International Journal of Alzheimer's Disease·Nathalie ArnalCarlos A Marra
Mar 28, 2012·Biochimica Et Biophysica Acta·Nathalie ArnalCarlos Alberto Marra
Dec 24, 2013·International Journal of Alzheimer's Disease·Nathalie ArnalCarlos A Marra
Nov 1, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Nathalie ArnalCarlos Alberto Marra
Oct 12, 2016·Biological Trace Element Research·Ying LiZeng-Ming Yang
May 20, 2019·Environmental Science and Pollution Research International·Nazim Husain, Riaz Mahmood
Mar 3, 2017·Environmental Science and Pollution Research International·Masoud PandehLyla Sedghian
Aug 18, 2012·Human & Experimental Toxicology·N ArnalC A Marra
Jun 26, 2017·Environmental Science and Pollution Research International·Heba El-Sayed MostafaNehal S Abouhashem
Jun 4, 2020·International Journal of Molecular Sciences·Jayant Patwa, Swaran Jeet Singh Flora
Apr 5, 2013·Toxicology and Industrial Health·Ali Akbar MalekiradMohammad Abdollahi
Jan 19, 2021·Nursing for Women's Health·Lena Crandell, Natalie Mohler
Feb 18, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Gul Nihal BuyukYaprak Engin-Ustun
Sep 4, 2020·Journal of Biochemical and Molecular Toxicology·Jeremiah ArowoogunOluwatosin A Adaramoye

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