PMID: 11315260Apr 24, 2001Paper

Alterations in cyclin D1 expression in esophageal squamous cell carcinoma in the Indian population

Journal of Cancer Research and Clinical Oncology
R MathewR Ralhan

Abstract

The p16/cyclin D1/pRb pathway plays a critical role in tumourigenesis. We recently reported alterations in expression of tumour suppressor gene products, p16 and pRb in esophageal cancer. Knowledge of alterations in cyclin D1, a vital component of this pathway in esophageal carcinomas from the Indian subcontinent, where the etiology and pathogenesis may be confounded by various unique dietary and environmental factors, is presently scanty. In order to bridge the gap between the accentuating incidence of esophageal cancer and aberrations in the components of this vital pathway, we analysed cyclin D1 expression in esophageal squamous cell carcinoma in the Indian population. Immunohistochemical analysis of cyclin D1 expression was carried out in paraffin-embedded sections of surgically resected esophageal squamous cell carcinomas (ESCC) (70 patients) and matched with histopathologically normal esophageal tissues from a distant site. The findings were correlated with clinicopathological parameters. Overexpression of cyclin D1 was observed in the tumour nuclei in 41 out of 70 (59%) patients. We found concomitant alterations in 16 and cyclin D1 (p16-/CycD1+ phenotype) in 16 of the 70 patients (23%), while alterations of pRb and cycli...Continue Reading

Citations

Jan 27, 2005·Journal of Cancer Research and Clinical Oncology·Patrapim SunpaweravongMarileila Varella-Garcia
Dec 3, 2003·Journal of Clinical Pathology·A EtgesV C Araújo
Sep 7, 2006·World Journal of Surgical Oncology·Ho-Sheng LinWillard E Fee
Apr 25, 2006·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·György Kövesi, Béla Szende
Nov 12, 2002·Surgical Oncology Clinics of North America·Wa'el el-Rifai, Steven M Powell
Feb 26, 2013·Oral Oncology·Rajakishore Mishra
Dec 30, 2003·International Journal of Cancer. Journal International Du Cancer·Ion CotarlaPriscilla A Furth
Feb 7, 2013·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M-T WangE-M Li

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