PMID: 6540376Jun 1, 1984Paper

Alterations in different populations of striatal dopamine receptors produced by 18 months continuous administration of cis- or trans-flupenthixol to rats

Neuropharmacology
K MurugaiahC D Marsden

Abstract

Administration of cis-flupenthixol (0.8-1.2 mg/kg per day) for 18 months enhanced stereotyped behaviour induced by apomorphine, bromocriptine and lergotrile, but not that induced by amphetamine or lisuride. Catalepsy induced by acute administration of haloperidol, trifluoperazine or cis-flupenthixol was reduced by continuous chronic intake of cis-flupenthixol. The number (Bmax) and dissociation constant (KD) of specific [3H]spiperone binding sites on striatal membranes was increased by chronic administration of cis-flupenthixol, but not trans-flupenthixol. In contrast, the Bmax and KD for specific binding of [3H]N,n-propylnorapomorphine were decreased by administration of cis-flupenthixol compared to the effect of the trans-isomer. Specific binding of [3H]piflutixol was unaffected by chronic administration of cis- or trans-flupenthixol, but chronic administration of cis-flupenthixol enhanced stimulation by dopamine of the activity of striatal adenylate cyclase. As a result of chronic continuous administration of cis-flupenthixol dopamine receptors in the striatum appeared to be supersensitive to most dopamine agonists but sub-sensitive to dopamine antagonists. This was reflected by increased numbers of D-2 antagonist receptor s...Continue Reading

References

Aug 15, 1979·European Journal of Pharmacology·A ClowC D Marsden
Jan 11, 1979·Nature·J W Kebabian, D B Calne
May 1, 1977·Neuropharmacology·P N ElliottR Miller
Jan 1, 1981·Psychopharmacology·J Hyttel
Mar 1, 1996·Harvard Review of Psychiatry·R J Baldessarini, F I Tarazi

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Citations

Jan 1, 1990·Psychopharmacology·C SchremmerT Ott
Jul 17, 1985·European Journal of Pharmacology·R G MacKenzie, M J Zigmond
Apr 1, 1986·Pharmacology, Biochemistry, and Behavior·A P Zwicker, H M Calil
Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·S Wolfarth, K Ossowska
Apr 1, 1987·Reviews in the Neurosciences·J L Waddington, K M O'Boyle
Jul 1, 1992·Reviews in the Neurosciences·A J Heritch
May 7, 2008·European Journal of Pharmacology·Mervan S AgovicShailesh P Banerjee

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