Alterations in dopamine clearance and catechol-O-methyltransferase activity by dopamine infusions in children

Critical Care Medicine
E AllenJ L Blumer

Abstract

To determine the role of catechol-O-methyltransferase (COMT) in the biodisposition of pharmacologic concentrations of dopamine. The study was an open-label dose escalation trial in which dopamine was employed as the sole exogenous catecholamine. The dosage was adjusted to achieve improvements in cardiac output or to augment renal function. A 16-bed pediatric intensive care unit serving both medical and surgical patients. The study was performed using 14 dopamine-treated and five untreated control patients. Children ranged in age from 16 days to 12 yrs; five of the treated patients and two of the untreated controls were female. All but one of the study patients were enrolled within 24 hrs of palliative or corrective surgery for congenital heart disease. Control patients had noncardiac surgical procedures. Both treated and control groups were similar with respect to severity of illness, as judged by Therapeutic Intervention Scoring System score. All treated patients received dopamine as a continuous intravenous infusion. Infusion rates were determined by caregivers and ranged from 3.0 to 20 micrograms/kg/min. Serial, timed blood samples were obtained from patients and control subjects for the determination of plasma dopamine conc...Continue Reading

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Citations

Dec 15, 2000·Progress in Pediatric Cardiology·S LatifiJ L Blumer
Feb 19, 2002·Paediatric Anaesthesia·P D Booker
Dec 15, 2000·Kidney International·S P BergerF J Van Der Woude
Jun 20, 2002·Critical Care Medicine·Joseph A CarcilloUNKNOWN American College of Critical Care Medicine Task Force Committee Members
Nov 9, 2004·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Jeffrey E SchmidtRobert F Tamburro
Mar 31, 2015·European Journal of Pharmacology·Jared W Young, Davide Dulcis
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Mar 22, 2002·The Journal of Pharmacology and Experimental Therapeutics·Maohe YanJeffrey L Blumer
Apr 16, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Maohe YanJeffrey L Blumer

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