Alterations in energy metabolism of hypertrophied rat cardiomyocytes: influence of propionyl-L-carnitine

Journal of Cardiovascular Pharmacology
L TorielliP Ferrari

Abstract

Alterations in energy metabolism, reduced fatty acid oxidation, and cardiac carnitine content have been implicated in the evolution from compensated to decompensated cardiac hypertrophy. We determined high-energy nucleotide levels in hypertrophied quiescent cardiomyocytes isolated from rat hearts 4 weeks after banding of abdominal aorta. In hypertrophied quiescent cardiomyocytes, a decrease in ATP content (p = 0.03), and ratios of ATP/total adenine nucleotides and of ATP/ADP were observed, together with an increase in ADP. In addition, palmitate, but not glucose oxidation, was markedly reduced in hypertrophied myocytes. In the presence of 25 microM propionyl-L-carnitine (PLC) or L-carnitine (LC), palmitate oxidation was significantly stimulated in hypertrophied myocytes. The ATP/ADP ratio was significantly increased only with PLC. This effect was not due to an enhanced PLC uptake, since total PLC uptake was 50% lower than that of LC. Changes in the energy generating system of quiescent myocytes occur early in pressure overload hypertrophy, and these alterations can be attenuated by PLC.

Citations

Oct 11, 2012·World Journal of Gastroenterology : WJG·Giuseppe MerraAntonio Gasbarrini
Apr 28, 2011·Nutrition Reviews·Carmen MingoranceMaria Alvarez de Sotomayor
Jul 1, 1997·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M Van BilsenG J Van der Vusse
Oct 23, 1997·Journal of Cardiac Failure·R Ferrari, F De Giuli

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