Alterations in expressed prostate secretion-urine PSA N-glycosylation discriminate prostate cancer from benign prostate hyperplasia

Oncotarget
Gaozhen JiaYinghao Sun

Abstract

The prostate specific antigen (PSA) test is widely used for early diagnosis of prostate cancer (PCa). However, its limited sensitivity has led to over-diagnosis and over-treatment of PCa. Glycosylation alteration is a common phenomenon in cancer development. Different PSA glycan subforms have been proposed as diagnostic markers to better differentiate PCa from benign prostate hyperplasia (BPH). In this study, we purified PSA from expressed prostate secretions (EPS)-urine samples from 32 BPH and 30 PCa patients and provided detailed PSA glycan profiles in Chinese population. We found that most of the PSA glycans from EPS-urine were complex type biantennary glycans. We observed two major patterns in PSA glycan profiles. Overall there was no distinct separation of PSA glycan profiles between BPH and PCa patients. However, we detected a significant increase of glycan FA2 and FM5A2G2S1 in PCa when compared with BPH patients. Furthermore, we observed that the composition of FA2 glycan increased significantly in advanced PCa with Gleason score ≥8, which potentially could be translated to clinic as a marker for aggressive PCa.

References

Jan 1, 1996·Springer Seminars in Immunopathology·V H Engelhard
Oct 29, 2005·Science·Scott A TomlinsArul M Chinnaiyan
Apr 17, 2007·Journal of Proteome Research·Zuzana KyselovaMilos V Novotny
Mar 4, 2008·Journal of Proteome Research·Alessio CeroniStuart M Haslam
Mar 20, 2009·The New England Journal of Medicine·Gerald L AndrioleUNKNOWN PLCO Project Team
Mar 20, 2009·The New England Journal of Medicine·Fritz H SchröderUNKNOWN ERSPC Investigators
May 5, 2009·European Urology·Scott A TomlinsJack A Schalken
Nov 6, 2009·Proceedings of the National Academy of Sciences of the United States of America·Steven R BarthelCharles J Dimitroff
Nov 26, 2009·BJU International·Lucas NogueiraJames A Eastham
Mar 5, 2010·CA: a Cancer Journal for Clinicians·Andrew M D WolfUNKNOWN American Cancer Society Prostate Cancer Advisory Committee
Aug 24, 2010·Omics : a Journal of Integrative Biology·Ariadna SarratsRosa Peracaula
Jan 11, 2011·Journal of Proteome Research·James N ArnoldPauline M Rudd
Aug 5, 2011·Science Translational Medicine·Scott A TomlinsArul M Chinnaiyan
Nov 1, 2011·Journal of Molecular Biology·Enrico A SturaFrédéric Ducancel
Sep 13, 2013·Science Translational Medicine·Shazia IrshadCory Abate-Shen
Apr 2, 2014·Therapeutic Advances in Urology·Stacy Loeb, William J Catalona
May 13, 2014·Biochemical and Biophysical Research Communications·Tohru YoneyamaYuki Tobisawa
Dec 3, 2014·The Journal of Urology·Stacy LoebWilliam J Catalona
Jan 7, 2015·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Mar 3, 2015·Advances in Cancer Research·Richard R DrakeJulius O Nyalwidhe
Jul 15, 2015·Nature Reviews. Urology·Michael L BluteDavid F Jarrard
Aug 21, 2015·Nature Reviews. Cancer·Salomé S Pinho, Celso A Reis
Jun 20, 2017·Nature Cell Biology·Ting WangYuhui Jiang

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Citations

Nov 20, 2018·Expert Review of Proteomics·Jan TkacPeter Kasak
Jul 17, 2020·Cancer Management and Research·Christopher J McNallyDeclan J McKenna
Apr 25, 2019·Nature Reviews. Urology·Neus Martínez-BoschPilar Navarro
Dec 9, 2020·Journal of Pharmaceutical and Biomedical Analysis·Balazs ReiderAndras Guttman
Aug 8, 2021·Cancers·Anna KałużaMirosława Ferens-Sieczkowska
Oct 19, 2019·Analytical Chemistry·Suttipong SuttapitugsakulRonghu Wu
Oct 15, 2021·Frontiers in Chemistry·Calvin R K BlaschkeRichard R Drake

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Methods Mentioned

BETA
glycosylation
sialylation
electrophoresis
immunoprecipitation
PCA
glycotransferases
biopsy

Software Mentioned

GlycoWorkbench
Cluster
JavaTreeview
Umetrics Simca
MassHunter Acquisition System

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